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Clinical Immunology Lab

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The Clinical Immunology Laboratory at Rosalind Franklin University was established in 1988 as a pioneering laboratory specializing in cutting-edge immunological tests. It was one of the first to provide immunological testing for the diagnosis of recurrent pregnancy losses and unexplained infertility. The laboratory offers innovative immune assays, using both immunological and molecular biology methodology and state-of-the-art instruments. It provides services to physicians and patients nationally and internationally.

The laboratory, being part of Rosalind Franklin University of Medicine and Science, has performed scientific research in the field of human reproduction for over two decades and has been established as a leading center in the area of reproductive immunology.

The laboratory continues to serve the physicians and patients with the implementation of new diagnostic assays.

About Us

The Clinical Immunology Laboratory at Rosalind Franklin University was established in 1988 to provide services and specialized tests in clinical immunology.

Among these specialized tests are assays for autoantibodies, flow cytometric based tests for phenotypes of white blood cells, cytotoxicity assays for nk function and assays for intracellular cytokines. In addition, molecular based assays for mutations of genes involved in coagulation abnormalities, HLA allele assays and tests for STDs are performed.

The Laboratory provides services for physicians in over 450 clinics in the United States and 30 countries.

At present the laboratory has 9 full time Medical Technologists, 1 Clinical Fellow, 1 Client Service Coordinator and 1 administrative assistant .

Fellowship

The Clinical Immunology Laboratory offers a 2 year Clinical Immunology Fellowship program for qualifying individuals who want to pursue a career in Clinical Diagnostic Immunology.

This program is only one of three in Immunology in the US that are accredited by the American Society of Microbiology, Committee on Postgraduate Educational Programs (CPEP).

Interested individuals should visit the American Society of Microbiology website to obtain information on requirements and application process.

Diagnostic Test Menu

HIPAA Information and Privacy Practices
HIPAA Information
Notice of Privacy Practices

Requisition Forms
Specialty Lab Requisition
Specimen Handling & Shipping Instructions
Patient Result Portal Registration

Immune Function Assays by Flow Cytometry
NK Cell Cytotoxicity Assay
Functional NK Assay with Prednisolone
TH1/TH2 Intracellular Cytokine Ratio
TH1/TH2 Cytokine Ratios by Flow Cytometry with IVIG
TH1/TH2 Cytokine Ratios by Flow Cytometry with Prednisolone
Reproductive Immunophenotype
Immunodeficiency Panel
Leukocyte Antibody Detection
Platelet Auto-antibodies

Autoimmune Assays
Anti-phospholipid Antibodies Panel
-Anti-cardiolipin
-Anti-phosphatidyl-ethanolamine
-Anti-phosphatidyl-serine
-Anti-phosphatidyl-glycerol
-Anti-phosphatidyl-inositol
-Anti-phosphatidic acid
Anti-β2 Glycoprotein I Antibodies
Anti-Nuclear Antibodies
Anti-DNA Antibodies Panel
-Anti-ssDNA
-Anti-dsDNA
-Anti-histones
-Anti-Scl-70
Anti-Extractable Nuclear Antibodies Panel
-Anti-Ro/SSA
-Anti-La/SSB
-Anti-RNP
-Anti-Sm
Anti-thyroid Antibodies Panel
-Anti-thyroglobulin
-Anti-thyroid peroxidase

Immunogenetics
Genotyping for HLA-A29 – Birdshot Chorioretinopathy
Genotyping for HLA-DQA/DQB – Celiac Disease Risk
Genotyping for HLA-B27 Disease Association - Spondyloarthritis
HLA-DQα Alleles
HLA-DQβ Alleles
HLA-A,-B,-C Alleles
HLA-DR Alleles
HLA-C Group Type
KIR Genotyping

Inherited Thrombophilia Panel
(Gene Polymorphisms)
Factor V Leiden Mutation
Factor VH1299R (HR2) Mutation
MTHFR C677T Mutation
MTHFR A1298C Mutation
PAI-1 4G/5G Mutation
Prothrombin G 20210A Mutation
HPA 1a/1b Mutation
β-Fibrinogen G455A Mutation
Factor XIII V34L Mutation

Endometrial Biopsy Sample Assays
Endometrial Immune Profile - Currently not available until further notice
Human herpesvirus-6 (HHV-6) qRT-PCR test - Currently not available until further notice
Decidualization Score, RNA Sequencing

Hormones
βhCG
Luteinizing Hormone (LH)
Follicle Stimulating Hormone (FSH)
Estradiol
Progesterone
Prolactin
Anti-Mullerian Hormone
Testosterone Total
Testosterone Total With Free Androgen Index
Sex Hormone Binding Globulin (SHBG)
Thyroid Stimulating Hormone (TSH)
Free T3
Free T4
Prostate Specific Antigen (PSA)