Center for Neurodegenerative Disease & Therapeutics Diseases

Alzheimer's

• Robert Marr
  
  • Chang JL, Hinrich AJ, Roman B, Norrbom M, Rigo F, Marr RA, Norstrom EM, Hastings ML. (2018) Targeting Amyloid-β Precursor Protein, APP, Splicing with Antisense Oligonucleotides Reduces Toxic Amyloid-β Production. Mol Ther. 26(6):1539-1551. PMID: 29628304
  • Lim PH, Wert SL, Tunc-Ozcan E, Marr R, Ferreira A, Redei EE. (2018) Premature hippocampus-dependent memory decline in middle-aged females of a genetic rat model of depression. Behav Brain Res. pii: S0166-4328(17)31740-0. PMID: 29490235
  • AJ Hinrich, FM Jodelka, JL Chang, D Brutman, A Bruno, CA Briggs, BD. James, GE Stutzmann, DA Bennett, SA Miller, F Rigo, RA Marr, ML Hastings (2015). Therapeutic correction of apoER2 splicing in Alzheimer’s disease mice using antisense oligonucleotides. EMBO Molecular Medicine, 8(4):328-45. PMID: 26902204
  • JA Bonds, Y Kuttner-Hirshler, N Bartolotti, MK Tobin; M Pizzi, RA Marr, O Lazarov (2015). Presenilin-1 dependent neurogenesis regulates hippocampal learning and memory. PLoS One, 10(6):e0131266. PMID: 26098332
• Judith A. Potashkin
  • Bottero V, Powers D, Yalamanchi A, Quinn JP, Potashkin JA. Key Disease Mechanisms Linked to Alzheimer's Disease in the Entorhinal Cortex. Int J Mol Sci. 2021 Apr 10;22(8):3915. doi: 10.3390/ijms22083915. PMID: 33920138; PMCID: PMC8069371.
  • Bottero V, Potashkin JA. A Comparison of Gene Expression Changes in the Blood of Individuals Consuming Diets Supplemented with Olives, Nuts or Long-Chain Omega-3 Fatty Acids. Nutrients. 2020 Dec 8;12(12):3765. doi: 10.3390/nu12123765. PMID: 33302351; PMCID: PMC7762614.
  • Santiago JA, Potashkin JA. The Impact of Disease Comorbidities in Alzheimer's Disease. Front Aging Neurosci. 2021 Feb 12;13:631770. doi: 10.3389/fnagi.2021.631770. PMID: 33643025; PMCID: PMC7906983.
• Grace E. Stutzmann
  
  • Chakroborty S, Hill E. Christian DT, Helfrich R, Riley S, Kapecki N, Mustaly S, Seiler FA, Schneider C, Peterson DA, West AR, Vertel BM, Frost WN, Stutzmann GE. (2019) Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer’s disease. Molecular Neurodegeneration, 22;14(1):7. PMID: 30670054
  • Schrank S, Barrington N, Stutzmann GE (2019) ‘Calcium handling defects and neurodegenerative disease’ In Calcium, Second Edition. Editors: Martin D. Bootman, Geert Bultynck, Grace E. Stutzmann, and Michael J. Berridge. Cold Spring Harbor, Cold Spring Harbor Laboratory Press. 499-524. PMID: 31427373
  • Mustaly S, Littlefield A, Stutzmann GE (2018) Calcium signaling deficits in glia and autophagic pathways contributing to neurodegenerative disease. 29(12): 1158-1175. PMID: 29634342
  • Briggs CA, Chakroborty S, Stutzmann GE (2017) Emerging pathways driving early synaptic pathology in Alzheimer’s disease. Biochem Biophys Res Commun. 483(4):988-997. PMID: 27659710
  • Lacampagne A, Liu X, Reiken S, Bussiere R, Meli AC, Lauritzen I, Teich AF, Zalk R, Saint N, Arancio O, Bauer C, Duprat F, Briggs CA, Chakroborty S, Stutzmann GE, Shelanski ML, Checler F, Chami M, Marks AR (2017) Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer’s disease-like pathologies and cognitive deficits. Acta Neuropathol, 134(5):749-767. doi: 10.1007/s00401-017-1733-7 PMID: 28631094
  • Chakroborty S, Kim J, Schneider C, West A, Stutzmann GE (2015) Nitric oxide signaling is recruited as a compensatory mechanism for sustaining synaptic plasticity in Alzheimer’s disease mice. Journal of Neuroscience, 35(17), 6893-902. doi: 10.1523/JNEUROSCI.4002-14.2015 PMID: 25926464

Brain Injury

• Robert Marr
  
  • Maigler KC, Buhr TJ, Park CS, Miller SA, Kozlowski DA, Marr RA. Assessment of the Effects of Altered Amyloid-Beta Clearance on Behavior following Repeat Closed-Head Brain Injury in Amyloid-Beta Precursor Protein Humanized Mice. J Neurotrauma. 2021 Mar;38(5):665-676. doi: 10.1089/neu.2020.6989. Epub 2021 Jan 8. PMID: 33176547; PMCID: PMC7898404.
  • F Klempin, RA Marr, DA Peterson (2012). Modification of Pax6 and Olig2 in adult hippocampal neurogenesis selectively induces stem cell fate and alters both neuronal and glial populations. Stem Cells, 30(3):500-9. PMID: 22162276
• Daniel A. Peterson
  • McDaid J, Briggs CA, Barrington NM, Peterson DA, Kozlowski DA, Stutzmann GE. Sustained Hippocampal Synaptic Pathophysiology Following Single and Repeated Closed-Head Concussive Impacts. Front Cell Neurosci. 2021 Mar 31;15:652721. doi: 10.3389/fncel.2021.652721. PMID: 33867941; PMCID: PMC8044326.
  • Jamnia N, Urban JH, Stutzmann GE, Chiren SG, Reisenbigler E, Marr R, Peterson DA, Kozlowski DA. (2017) A Clinically Relevant Closed-Head Model of Single and Repeat Concussive Injury in the Adult Rat Using a Controlled Cortical Impact Device. Journal of Neurotrauma 3:1351-1363.
  • Doerr J, Schwarz MK, Wiedermann D, Leinhaas A, Jakobs A, Schloen F, Schwarz I, Diedenhofen M, Braun NC, Koch P, Peterson DA, Kubitscheck U, Hoehn M, Brüstle O. (2017) Whole-brain 3D mapping of human neural transplant innervation. Nature Communications 8:14162. 
  • Kuhn HG, Eisch AJ, Spalding K, Peterson DA. (2016) Detection and Phenotypic Characterization of Adult Neurogenesis. Cold Spring Harbor Perspectives in Biology 8:a025981.
• Grace E. Stutzmann
  • McDaid J, Briggs CA, Barrington NM, Peterson DA, Kozlowski DA, Stutzmann GE. Sustained Hippocampal Synaptic Pathophysiology Following Single and Repeated Closed-Head Concussive Impacts. Front Cell Neurosci. 2021 Mar 31;15:652721. doi: 10.3389/fncel.2021.652721. PMID: 33867941; PMCID: PMC8044326.
  • Jamnia N, Urban JH, Stutzmann GE, Chiren S, Reisenbigler E, Marr R, Peterson DA, Kozlowski DA (2016) A clinically relevant closed-head model of single and repeat concussive injury in the adult rat using a controlled cortical impact device. J Neurotrauma. 34(7):1351-1363. PMID: 27762651
  • Shim S, Stutzmann GE (2016) Inhibition of glycogen synthase kinase-3: an emerging target in the treatment of traumatic brain injury. Journal of Neurotrauma. 33(23):2065-2076. PMID: 26979735

Diabetes

• Daniel A. Peterson
  
  • Shin, L. and Peterson, D.A. (2012) Impaired therapeutic capacity of autologous stem cells in a model of type 2 diabetes. Stem Cells Translational Medicine, 1:125-135.

Parkinson's

• Judith A. Potashkin
  
  • Santiago JA, Bottero V, Potashkin JA. (2018) Evaluation of RNA Blood Biomarkers in the Parkinson's Disease Biomarkers Program. Front Aging Neurosci. 10:157.
  • Santiago JA, Bottero V, Potashkin JA. (2017) Biological and Clinical Implications of Comorbidities in Parkinson's Disease. Front Aging Neurosci. 9:394.
  • Santiago JA, Potashkin JA. (2017) Evaluation of RNA Blood Biomarkers in Individuals at Risk of Parkinson's Disease. J Parkinsons Dis. 7:653.
  • Santiago JA, Bottero V, Potashkin JA. (2017) Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology. Front Aging Neurosci. 9:166
  • Katrina Gwinn, Karen David, Christine Swanson-Fischer, Roger Albin, Coryse St. Hillaire-Clark, Beth-Anne Sieber, Codrin Lungu, F. DuBois Bowman, Roy N. Alcalay, Debra Babcock, Ted M. Dawson, Richard B. Dewey, Tatiana Foroud, Dwight German, Xuemei Huang, Vlad Petyuk, Judith A. Potashkin, Rachel Saunders-Pullman, Margaret Sutherland, David Walt, Andrew B. West, Jing Zhang, Alice Chen-Plotkin, Clemens R. Scherzer, David Vaillancourt, and Liana S. Rosenthal. Parkinson’s disease biomarkers: Perspective from the NINDS Parkinson’s disease biomarkers program. Biomark Med. 11, 451-473.

Wound Healing

• Daniel A. Peterson
  
  • Shin, L. and Peterson, D.A. (2013) Human mesenchymal stem cell grafts enhance normal and impaired wound healing by recruiting existing endogenous tissue stem/progenitor cells. Stem Cell Translational Medicine 2:33-42.