In this section
Raúl Gazmuri, MD, PhD, FCCM
Dr. Gazmuri is Professor (tenure-track) in the Department of Medicine (primary appointment) and in the Department of Physiology & Biophysics (secondary appointment). Dr. Gazmuri is also Director of the Resuscitation Institute at RFUMS where he leads basic and translational research on acute life-threatening conditions including cardiac arrest and various forms of circulatory shock with focus on bioenergetic function and identifying novel therapeutic approaches. At the Captain James A. Lovell Federal Health Care Center (FHCC), Dr. Gazmuri is the Section Chief of Critical Care Medicine and ICU Director.
Dr. Gazmuri obtained his Medical Degree and Internal Medicine training from the University of Chile and practiced Critical Care Medicine before travelling to the United States in 1986 for a research fellowship at today’s RFUMS under the mentorship of late Professor Max Harry Weil, MD, PhD (one of the founding fathers of Critical Care Medicine). Dr. Gazmuri devoted three years as a full-time research fellow and five additional years as a Critical Care Fellow, PhD student, and junior faculty under Dr. Weil’s mentorship. In 1994, he earned a PhD degree in Physiology & Biophysics from RFUMS and in 1997 he was inducted Fellow of the American College of Critical Care Medicine.
Dr. Gazmuri has contributed to the field of Resuscitation and Critical Care Medicine with more than 200 publications and has received – as primary and/or senior author – multiple awards at national scientific meetings. He has served as member of the Basic Life Support, Advanced Life Support, Scientific Subcommittee of the Emergency Cardiovascular Care at the American Heart Association (AHA), and as member of the organizing committee of the AHA Resuscitation Science Symposium. He has also served on the International Liaison Committee on Resuscitation (ILCOR) involved in the development of CPR Guidelines and frequently participates on NIH and VHA Study Section panels.
In 2017, Dr. Gazmuri founded Resuscitation Therapeutics, Inc. with the goal of facilitating clinical translation of new therapies and strategies for life-threatening medical emergencies occurring in pre-hospital and hospital environments.
Publications
Listed below are publications from 2020 onwards. A complete list of original peer-reviewed publications is available at My Bibliography (maintained by the US National Library of Medicine).
Book Chapters
- Gazmuri RJ, Santonocito C, Aiello SR, Donghee K. Ch 72. Ventricular Arrhythmias. In: Vincent, Moore, Bellomo, Marini (eds). Textbook of Critical Care, 8th Edition. Philadelphia: Elsevier Inc., 2024:Ch.72;pp.588-597.
- Gazmuri RJ. Cardioversion and Defibrillation. In: Vincent, Moore, Bellomo, Marini (eds). Textbook of Critical Care, 8th Edition. Philadelphia: Elsevier Inc., 2024:Online Ch.E6:1370.e83.
- Gazmuri RJ. Transvenous and Transcutaneoaus Cardiac Pacing. In: Vincent, Moore, Bellomo, Marini (eds). Textbook of Critical Care, 8th Edition. Philadelphia: Elsevier Inc., 2024.Online Ch.E7:1370.e85.
Peer-Reviewed Original Scientific Articles
- Radhakrishnan J, Baetiong A, Gazmuri RJ. Constitutive cyclophilin-D ablation in mice increases exercise and cognitive-behavioral performance under normoxic and hypoxic conditions. Physiol Behav 2020 May 15;219:112828. doi: 10.1016/j.physbeh.2020.112828. Epub 2020 Feb 13.
- Apigo M, Schechtman J, Dhliwayo N, Al Tameemi M, Gazmuri RJ. Development of a work of breathing scale and monitoring need of intubation in COVID-19 pneumonia. Crit Care 2020;24(1):477. Published 2020 Jul 31. doi:10.1186/s13054-020-03176-y.
- Nadeem A, Fanapour P, Apigo M, Kim S, George S, Khan M, Shahid A, Patel C, Carnate R, Gazmuri RJ. COVID-19 pneumonia: Guiding the decision to intubate based on work of breathing assessment independent of oxygenation. Int J Crit Care Emerg Med 2021, 7:126. DOI: 10.23937/2474-3674/1510126
- Aiello S, Mendelson JB, Baetiong A, Radhakrishnan J, Gazmuri RJ. Targeted delivery of electrical shocks and epinephrine, guided by ventricular fibrillation amplitude spectral area, reduces electrical and adrenergic myocardial burden, improving survival in swine. J Am Heart Assoc 2021;10:e023956. DOI: 10.1161/JAHA.121.023956
- Radhakrishnan J, Baetiong A, Gazmuri RJ. Enhanced Oxygen Utilization Efficiency With Concomitant Activation of AMPK-TBC1D1 Signaling Nexus in Cyclophilin-D Conditional Knockout Mice. Front Physiol. 2021 Dec 8;12:756659. doi: 10.3389/fphys.2021.756659. PMID: 34955879; PMCID: PMC8692870.
Review Articles
- Considine J, Gazmuri RJ, Perkins GD, Kudenchuk PJ, Olasveengen TM, Vaillancourt C, Nishiyama C, Hatanaka T, Mancini ME, Chung SP, Morley P. Chest compression components (rate, depth, chest wall recoil and leaning): a scoping review. Resuscitation 2020 Jan 1;146:188-202. doi: 10.1016/j.resuscitation.2019.08.042. Epub 2019 Sep 16. PMID: 31536776
- Gazmuri RJ, de Gomez CA. From a pressure-guided to a perfusion-centered resuscitation strategy in septic shock: Critical literature review and illustrative case. J Crit Care 2020;56:294-304, doi: 10.1016/j.jcrc.2019.11.008. Epub;%2020 Jan 8.
Letters to the Editor
- Shahid A, Fanapour P, Gazmuri RJ. Restriction of Intravenous Fluid in ICU Patients with Septic Shock. N Engl J Med 2022 Sep 1;387(9):856. doi: 10.1056/NEJMc2210366. (PMID: 36053519).
Editorials/Commentaries
- Gazmuri RJ, Dhliwayo N. From a toilet plunger to head-up CPR: Bundling systemic and regional venous return augmentation to improve the hemodynamic efficacy of chest compression. Resuscitation 2020 Feb 20. pii: S0300-9572(20)30080-0. doi: 10.1016/j.resuscitation.2020.02.014. [Epub ahead of print]. PMID: 32088256
- Gazmuri RJ, de Gomez CA. Septic shock patients with adequate tissue perfusion parameters still need the recommended minimal Mean Arterial Pressure: Not really. J Crit Care 2020;56:308-310, doi: 10.1016/j.jcrc.2020.01.009.
- Gazmuri RJ. Rapid Response to: The curious case of the Danish mask study -BMJ 2020;371:m4586 - https://www.bmj.com/content/371/bmj.m4586/rr-2
- Gazmuri RJ. Tapping on Pulseless Electrical Activity: An Opportunity for Improving Resuscitation Outcomes? J Am Heart Assoc. 2021 Jun 14:e021798. doi: 10.1161/JAHA.121.021798. Epub ahead of print. PMID: 34121412.
- Gazmuri RJ, Ayoub I. Ventilation During CPR: A Challenge to Guidelines and a Call for Research on Lingering Scientific Gaps. Resuscitation 2023;109811.
Current Investigator- Initiated Grants
| 2022-2025 | Project: Attenuation of Reperfusion Injury by Gliflozins During Cardiac Arrest Leading to Improved Post-Resuscitation Myocardial Function and Survival Source: BLR&D Merit Review Award (I01BX005705) Role: Principal Investigator |
| 2024-2025 | Project: Self-Operating System for Circulatory Management of Sepsis, Severe Sepsis, and Septic Shock Source: DePaul-RFUMS Pilot Grant Project Role: Co-Principal Investigator (conducting experiments at the Resuscitation Institute). |
| 2024-2025 | Project: Does Selective Peripheral α2-Adrenoceptor Stimulation during Cardiac Resuscitation Improves Survival with Favorable Neurologic Outcome Compared to Epinephrine? Source: Monica Ply Research Innovation Award Role: Principal Investigator |
| 2024-2026 | Project: Selective Targeting of Peripheral α2-Adrenoceptors with α-Methylnorepinephrine as a Superior Alternative to Epinephrine for Resuscitation from Cardiac Arrest Sponsor: ZOLL Foundation, Inc. Duration: 24 months Role: Mentor Principal Investigator: Armin Razi, MD, Research Fellow in the Resuscitation Institute at Rosalind Franklin University of Medicine and Science. |
| 2024-2026 | Project: Optimizing the Hemodynamic Management of Septic Shock by Continuous Monitoring of Microcirculatory Parameters Sponsor: ZOLL Foundation, Inc. Duration: 24 months Role: Mentor Principal Investigator: Moaz Bin Saeed, MBBS, Research Fellow in the Resuscitation Institute at Rosalind Franklin University of Medicine and Science. |