In this section
Jeremy Amiel Rosenkranz, PhD, MS
Cellular and Molecular Pharmacology Discipline
Center for Neurobiology of Stress Resilience and Psychiatric Disorders
Amiel Rosenkranz graduated from the University of Pittsburgh in 1997. He remained at the University of Pittsburgh to earn the MS degree in 1999 and the PhD in 2002, both in Neuroscience. Following postdoctoral work at the Baylor College of Medicine and University of Texas-Austin he joined the faculty of the Chicago Medical School in 2007 in the Cellular and Molecular Pharmacology discipline.
Research
Neurophysiology of Emotion and Memory
A dysfunction in the production, influence or perception of emotion is at the core of several psychiatric disorders. The amygdala is part of a system that mediates the influence of emotion on behavior and memory formation. In this laboratory we examine 1) how the amygdala influences these processes, 2) how it changes during learning, and 3) how it is disrupted in animal models of psychiatric disorders.
Modulation of synaptic integration
Synaptic inputs can drive neuronal activity. Their influence on neuronal output will be determined, in part, by integrative properties of the neuron. These properties are influenced by many factors, including monoamines and peptides. In this laboratory we examine how integrative properties are modified, and what role the dendrites play in this modulation.
Publications
Ferrara NC, Mrackova E, Loh MK, Padival M, Rosenkranz JA. Fear Learning Enhances Prefrontal Cortical Suppression of Auditory Thalamic Inputs to the Amygdala in Adults, but Not Adolescents. Int J Mol Sci. 2020;21(8):3008. Published 2020 Apr 24. doi:10.3390/ijms21083008
Ferrara NC, Trask S, Rosenkranz JA. Maturation of amygdala inputs regulate shifts in social and fear behaviors: A substrate for developmental effects of stress. Neurosci Biobehav Rev. 2021;125:11-25. doi:10.1016/j.neubiorev.2021.01.021
Loh MK, Rosenkranz JA. Shifts in Medial Orbitofrontal Cortex Activity from Adolescence to Adulthood. Cereb Cortex. 2022;32(3):528-539. doi:10.1093/cercor/bhab231
Ferrara NC, Trask S, Avonts B, Loh MK, Padival M, Rosenkranz JA. Developmental Shifts in Amygdala Activity during a High Social Drive State. J Neurosci. 2021;41(45):9308-9325. doi:10.1523/JNEUROSCI.1414-21.2021
Loh MK, Ferrara NC, Torres JM, Rosenkranz JA. Medial orbitofrontal cortex and nucleus accumbens mediation in risk assessment behaviors in adolescents and adults. Neuropsychopharmacology. 2022;47(10):1808-1815. doi:10.1038/s41386-022-01273-w
Munshi S, Ritger A, Rosenkranz AJ. Induction of Repeated Social Defeat Stress in Rats. Bio Protoc. 2022;12(3):e4306. Published 2022 Feb 5. doi:10.21769/BioProtoc.4306
Vantrease JE, Avonts B, Padival M, DeJoseph MR, Urban JH, Rosenkranz JA. Sex differences in the Activity of Basolateral Amygdalar Neurons that Project to the Bed Nucleus of the Stria Terminalis and their Role in Anticipatory Anxiety [published online ahead of print, 2022 Apr 26]. J Neurosci. 2022;42(22):4488-4504. doi:10.1523/JNEUROSCI.1499-21.2022
Loh MK, Rosenkranz JA. The medial orbitofrontal cortex governs reward-related circuits in an age-dependent manner [published online ahead of print, 2022 May 12]. Cereb Cortex. 2022;bhac182. doi:10.1093/cercor/bhac182
Ferrara NC, Trask S, Yan L, Padival M, Helmstetter FJ, Rosenkranz JA. Isolation driven changes in Iba1-positive microglial morphology are associated with social recognition memory in adults and adolescents. Neurobiol Learn Mem. 2022;192:107626. doi:10.1016/j.nlm.2022.107626
Ferrara NC, Trask S, Ritger A, Padival M, Rosenkranz JA. Developmental differences in amygdala projection neuron activation associated with isolation-driven changes in social preference. Front Behav Neurosci. 2022;16:956102. Published 2022 Aug 24. doi:10.3389/fnbeh.2022.956102
Munshi S, Loh MK, Ferrara N, DeJoseph MR, Ritger A, Padival M, Record MJ, Urban JH, Rosenkranz JA. Repeated stress induces a pro-inflammatory state, increases amygdala neuronal and microglial activation, and causes anxiety in adult male rats. Brain Behav Immun. 2020 84:180-199.
Munshi S, Rosenkranz JA, Caccamise A, Wolf ME, Corbett CM, Loweth JA. Cocaine and chronic stress exposure produce an additive increase in neuronal activity in the basolateral amygdala. Addict Biol. 2019 Nov 21:e12848.
Blume SR, Padival M, Urban JH, Rosenkranz JA. Disruptive effects of repeated stress on basolateral amygdala neurons and fear behavior across the estrous cycle in rats. Sci Rep. 2019 9:12292.
Munshi S, Parrilli V, Rosenkranz JA. Peripheral anti-inflammatory cytokine Interleukin-10 treatment mitigates interleukin-1β - induced anxiety and sickness behaviors in adult male rats. Behav Brain Res. 2019 372:112024.
Selleck RA, Zhang W, Samberg HD, Padival M, Rosenkranz JA. Limited prefrontal cortical regulation over the basolateral amygdala in adolescent rats. Sci Rep. 2018 8:17171.
Munshi S, Rosenkranz JA. Effects of Peripheral Immune Challenge on In Vivo Firing of Basolateral Amygdala Neurons in Adult Male Rats. Neuroscience. 2018 390:174-186.
Blume SR, Freedberg M, Vantrease JE, Chan R, Padival M, Record MJ, DeJoseph MR, Urban JH, Rosenkranz JA. Sex- and Estrus-Dependent Differences in Rat Basolateral Amygdala. J Neurosci. 2017 37:10567-10586.
Twining RC, Vantrease JE, Love S, Padival M, Rosenkranz JA. An intra-amygdala circuit specifically regulates social fear learning. Nat Neurosci. 2017 20:459-469.
Glynn RM, Rosenkranz JA, Wolf ME, Caccamise A, Shroff F, Smith AB, Loweth JA. Repeated restraint stress exposure during early withdrawal accelerates incubation of cue-induced cocaine craving. Addict Biol. 2018 23:80-89.
Zhang W, Rosenkranz JA. Effects of Repeated Stress on Age-Dependent GABAergic Regulation of the Lateral Nucleus of the Amygdala. Neuropsychopharmacology. 2016 41:2309-23.
Adams T, Rosenkranz JA. Social Isolation During Postweaning Development Causes Hypoactivity of Neurons in the Medial Nucleus of the Male Rat Amygdala. Neuropsychopharmacology. 2016 41:1929-40.
Jaisinghani S, Rosenkranz JA. Repeated social defeat stress enhances the anxiogenic effect of bright light on operant reward-seeking behavior in rats. Behav Brain Res. 2015 290:172-9.
Padival MA, Blume SR, Vantrease JE, Rosenkranz JA. Qualitatively different effect of repeated stress during adolescence on principal neuron morphology across lateral and basal nuclei of the rat amygdala. Neuroscience. 2015 291:128-45.
Zhang W, Hetzel A, Shah B, Atchley D, Blume SR, Padival MA, Rosenkranz JA. Greater physiological and behavioral effects of interrupted stress pattern compared to daily restraint stress in rats. PLoS One. 2014 Jul 11;9:e102247. eCollection 2014.
Hetzel A, Rosenkranz JA. Distinct effects of repeated restraint stress on basolateral amygdala neuronal membrane properties in resilient adolescent and adult rats. Neuropsychopharmacology. 2014 39:2114-30.
Padival MA, Blume SR, Rosenkranz JA. Repeated restraint stress exerts different impact on structure of neurons in the lateral and basal nuclei of the amygdala. Neuroscience. 2013 246:230-42.
Zhang W, Rosenkranz JA. Repeated restraint stress enhances cue-elicited conditioned freezing and impairs acquisition of extinction in an age-dependent manner. Behav Brain Res. 2013 248:12-24.
Padival M, Quinette D, Rosenkranz JA. Effects of Repeated Stress on Excitatory Drive of Basal Amygdala Neurons In Vivo. Neuropsychopharmacology. 2013 38:1748-62.
Yusufishaq S, Rosenkranz JA. Post-weaning social isolation impairs observational fear conditioning. Behav Brain Res. 2013 242:142-9.
Rosenkranz JA. In vivo voltage-dependent influences on summation of synaptic potentials in neurons of the lateral nucleus of the amygdala. Neuroscience. 2012 226:101-18.
Zhang W, Rosenkranz JA. Repeated restraint stress increases basolateral amygdala neuronal activity in an age-dependent manner. Neuroscience. 2012 226:459-74.
Atchley D, Hankosky ER, Gasparotto K, Rosenkranz JA. Pharmacological enhancement of calcium-activated potassium channel function reduces the effects of repeated stress on fear memory. Behav Brain Res. 2012 232:37-43.
Hetzel A, Meredith GE, Rademacher DJ, Rosenkranz JA. Effect of amphetamine place conditioning on excitatory synaptic events in the basolateral amygdala ex vivo. Neuroscience. 2012 206:7-16.
Rosenkranz JA. Neuronal activity causes rapid changes of lateral amygdala neuronal membrane properties and reduction of synaptic integration and synaptic plasticity in vivo. J Neurosci. 2011 31:6108-20.
Rosenkranz JA, Venheim ER, Padival M. Chronic Stress Causes Amygdala Hyperexcitability in Rodents. Biol Psychiatry. 2010 67:1128-36.
Rademacher DJ, Rosenkranz JA, Morshedi MM, Sullivan EM, Meredith GE. Amphetamine-associated contextual learning is accompanied by structural and functional plasticity in the basolateral amygdala. J Neurosci. 2010 30:4676-86.
Rosenkranz JA, Frick A, Johnston D. Kinase-dependent modification of dendritic excitability after long-term potentiation. J Physiol. 2009 587(Pt 1):115-25.
Rosenkranz JA, Johnston D. State-dependent modulation of amygdala inputs by dopamine-induced enhancement of sodium currents in layer V entorhinal cortex. J Neurosci. 2007 27:7054-69.
Rosenkranz JA, Johnston D. Dopaminergic regulation of neuronal excitability through modulation of Ih in layer V entorhinal cortex. J Neurosci. 2006 26:3229-44.
Rosenkranz JA, Buffalari DM, Grace AA. Opposing influence of basolateral amygdala and footshock stimulation on neurons of the central amygdala. Biol Psychiatry. 2006 59:801-11.
Correll CM, Rosenkranz JA, Grace AA. Chronic cold stress alters prefrontal cortical modulation of amygdala neuronal activity in rats. Biol Psychiatry. 2005 58:382-91.
Kroner S, Rosenkranz JA, Grace AA, Barrionuevo G. Dopamine modulates excitability of basolateral amygdala neurons in vitro. J Neurophysiol. 2005 93:1598-610.
West AR, Floresco SB, Charara A, Rosenkranz JA, Grace AA. Electrophysiological interactions between striatal glutamatergic and dopaminergic systems. Ann N Y Acad Sci. 2003 1003:53-74. Review.
Rosenkranz JA, Moore H, Grace AA. The prefrontal cortex regulates lateral amygdala neuronal plasticity and responses to previously conditioned stimuli. J Neurosci. 2003 23:11054-64.
Rosenkranz JA, Grace AA. Affective conditioning in the basolateral amygdala of anesthetized rats is modulated by dopamine and prefrontal cortical inputs. Ann N Y Acad Sci. 2003 985:488-91. No abstract available.
Grace AA, Rosenkranz JA. Regulation of conditioned responses of basolateral amygdala neurons. Physiol Behav. 2002 77:489-93. Review.
Rosenkranz JA, Grace AA. Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning. Nature. 2002 417:282-7.
Rosenkranz JA, Grace AA. Cellular mechanisms of infralimbic and prelimbic prefrontal cortical inhibition and dopaminergic modulation of basolateral amygdala neurons in vivo. J Neurosci. 2002 22:324-37.
Rosenkranz JA, Grace AA. Dopamine attenuates prefrontal cortical suppression of sensory inputs to the basolateral amygdala of rats. J Neurosci. 2001 21:4090-103.
Rosenkranz JA, Grace AA. Modulation of basolateral amygdala neuronal firing and afferent drive by dopamine receptor activation in vivo. J Neurosci. 1999 19:11027-39.