Marina E. Wolf, Ph.D

Professor and Chair 
Department of Neuroscience
Chicago Medical School
Room 2.262
Building: BSB
Phone: 847.578.8659
Fax: 847.578.8515
Sun X, Milovanovic M, Zhao Y, Wolf ME (2008) Acute and chronic dopamine receptor stimulation modulates AMPA receptor trafficking in nucleus accumbens neurons co-cultured with prefrontal cortex neurons. J Neurosci 28:4216-4230. PMC2667279

Conrad KL, Tseng KY, Uejima JL, Reimers JM, Heng LJ, Shaham Y, Marinelli M, Wolf ME (2008) Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature 454:118-121. PMC2574981

Gao C, Wolf ME (2008) Dopamine receptors regulate NMDA receptor surface expression in prefrontal cortex neurons. J Neurochem 106(6):2489-2501. PMID: 18673451

Nelson CL, Milovanovic M, Wetter JB, Ford KA, Wolf ME (2009) Behavioral sensitization to amphetamine is not accompanied by changes in glutamate receptor surface expression in the rat nucleus accumbens. J Neurochem 109:35–51. PMID: 19183251

Ford KA, Wolf ME, Hu X-T (2009) Plasticity of L-type Ca2+ channels after cocaine withdrawal. Synapse 63(8):690-697. PMID: 19360908

Boudreau AC, Ferrario CR, Glucksman M, Wolf ME (2009) Signaling pathway adaptations and novel protein kinase A substrates related to behavioral sensitization to cocaine. J Neurochem 110:363-377. PMC2856133

Sun X, Wolf ME (2009) Nucleus accumbens neurons exhibit synaptic scaling that is occluded by repeated dopamine pre-exposure.  Eur J Neurosci 30:539-550. PMID: 19674091

Ferrario CR, Li X, Wang X, Reimers JM, Uejima JL, Wolf ME (2010) The role of glutamate receptor redistribution in locomotor sensitization to cocaine. Neuropsychopharmacology 35:818-833. PMC3014646

Conrad KL, Ford KA, Marinelli M, Wolf ME (2010) Dopamine receptor expression and distribution dynamically change in the nucleus accumbens after withdrawal from cocaine self-administration. Neuroscience 169:182-194. PMC2901771

Ferrario CR, Li X, Wolf ME (2011) Effects of acute cocaine or dopamine receptor agonists on AMPA receptor distribution in the nucleus accumbens. Synapse 65:54-63. PMC2965794

Reimers JM, Milovanovic M, Wolf ME (2011) Quantitative analysis of AMPA receptor subunit composition in addiction-related brain regions. Brain Res 1367:223-233. PMC3005033

Ferrario CR, Loweth JA, Milovanovic M, Wang X, Wolf ME (2011) Distribution of AMPA receptor subunits and TARPs in synaptic and extrasynaptic membranes of the adult rat nucleus accumbens. Neurosci Lett 490:180-184. PMC3038183

Ferrario CR, Loweth JA, Milovanovic M, Ford KA, Galiñanes GL, Heng L-J, Tseng KY, Wolf ME (2011) Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca2+-permeable AMPA receptors during the incubation of cocaine craving. Neuropharmacology 61:1141-1151. PMC3094740

McCutcheon JE, Wang X, Tseng KY, Wolf ME*, Marinelli M* (2011) Calcium-permeable AMPA receptors are present in nucleus accumbens synapses after long withdrawal from cocaine self-administration but not experimenter-administered cocaine. J Neurosci 31:5737-5743. (*co-senior authors). PMC3157976

Li X, Wolf ME (2011) Brain-derived neurotrophic factor rapidly increases AMPA receptor surface expression in rat nucleus accumbens. Eur J Neurosci 34:190-198. PMC3936351

Li X, Wolf ME (2011) Visualization of virus-infected brain regions using a GFP-illuminating flashlight enables accurate and rapid dissection for biochemical analysis. J Neurosci Meth 201:177-179. PMC3176337

McCutcheon JE, Loweth JA, Ford KA, Marinelli M, Wolf ME*, Tseng KY* (2011) Group I mGluR activation reverses cocaine-induced accumulation of calcium-permeable AMPA receptors in nucleus accumbens synapses via a protein kinase C-dependent mechanism. J Neurosci 31:14536 –14541. (*co-senior authors) PMC3220940

Boudreau AC, Milovanovic M, Conrad KL, Nelson CL, Ferrario CR, Wolf ME (2012) A protein crosslinking assay for measuring cell surface expression of glutamate receptor subunits in t he rodent brain after in vivo treatments. Curr Protoc Neurosci 59:5.30.1-5.30.19. PMC3356776

Ferrario CR, Goussakov I, Stutzmann GE, Wolf ME (2012) Withdrawal from cocaine self-administration alters NMDA receptor-mediated Ca2+ entry in nucleus accumbens dendritic spines. PLoS One 7(8): e40898. PMC3411692

Li X, DeJoseph MR, Urban JH, Bahi A, Dreyer J-L, Loweth AJ, Ferrario CR, Ford KA, Wolf ME (2013) Different roles of BDNF in nucleus accumbens core versus shell during the incubation of cue-induced cocaine craving and its long-term maintenance. J Neurosci 33: 1130-1142. PMC3711541

Purgianto A, Scheyer AF, Loweth JA, Ford KA, Tseng KY, Wolf ME (2013) Different adaptations in AMPA receptor transmission in the nucleus accumbens after short versus long access cocaine self-administration regimens. Neuropsychopharmacol 38:1789–1797. PMC3717554

Wang X, Cahill ME, Werner CT, Christoffel DJ, Golden SA, Xie Z, Loweth JA, Marinelli M, Russo SJ, Penzes P, Wolf ME (2013) Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity, enabling incentive sensitization. J Neurosci 33:11012-11022. PMC3718375

Lee BR, Ma Y-Y, Huang YH, Wang X, Otaka M, Ishikawa M, Neumann PA, Graziane NM, Brown TE, Suska A, Guo C, Lobo MK, Sesack SR, Wolf ME, Nestler EJ, Shaham Y, Schlüter OM, Dong Y (2013) Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving. Nat Neurosci 16(11):1644-1651. PMC3815713

Plaza-Zabala A, Li X, Milovanovic M, Loweth JA, Maldonado R, Berrendero F, Wolf ME (2013) An investigation of interactions between hypocretin/orexin signaling and glutamate receptor surface expression in the rat nucleus accumbens under basal conditions and after cocaine exposure. Neurosci Lett 557 Pt B:101-106. PMC3869201

Selvakumar B, Campbell PW, Milovanovic M, Park DJ, West AR, Snyder SH, Wolf ME (2014) AMPA receptor upregulation in the nucleus accumbens shell of cocaine-sensitized rats depends upon S-nitrosylation of stargazin. Neuropharmacology 77:28-38. (*joint first authors). PMC3934570

Loweth JA, Scheyer AF, Milovanovic M, LaCrosse AL, Flores-Barrera E, Werner CT, Li X, Ford KA, Le T, Olive MF, Szumlinski KK, Tseng KY*, Wolf ME* (2014) Synaptic depression via positive allosteric modulation of mGluR1 suppresses cue-induced cocaine craving. Nat Neurosci 17(1):73-80. PMID: 24270186 (PMCID in progress).

Scheyer AF, Wolf ME*, Tseng KY* (2014) A protein synthesis-dependent mechanism sustains calcium-permeable AMPA receptor transmission in nucleus accumbens synapses during withdrawal from cocaine self-administration. J Neurosci 34(8):3095-3100. PMID: 24553949 (PMCID in progress).

Reimers JA, Loweth JA, Wolf ME (2014) BDNF contributes to both rapid and homeostatic alterations in AMPA receptor surface expression in nucleus accumbens medium spiny neurons. Eur J Neuroscience (in press – accepted 10/12/13) (special issue on Synaptic Basis of Disease)




Wolf ME (2010a) Regulation of AMPA receptor trafficking in the nucleus accumbens by dopamine and cocaine. Neurotoxicol Res 18:393–409. PMID: 20361291

Wolf ME (2010b) The Bermuda triangle of cocaine-induced neuroadaptations. TINS 33:391-398. PMID: 20655604

Wolf ME, Tseng KY (2012) Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how and why? Front Molecular Neurosci 5:72. PMID: 22754497.

Loweth JA, Tseng KY, Wolf ME (2013) Using metabotropic glutamate receptors to modulate cocaine’s synaptic and behavioral effects: mGluR1 finds a niche. Current Opin Neurobiol 23(4):500-506. PMC3664109

Loweth JA, Tseng KY, Wolf ME (2014) Neuroadaptations in the nucleus accumbens contributing to incubation of cocaine craving. Neuropharmacol 76 Pt B: 287-300. PMC3836860

Life in Discovery
Neuroscience Faculty
3333 Green Bay Road, North Chicago, Il 60064-3095 • 847-578-3000