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Anthony R. West, Ph.D.

Associate Professor
Department of Neuroscience
Chicago Medical School
Room 2.278
Building: BSB
Phone: 847.568.8658
Fax: 847.578.8515
Recent Peer Reviewed Publications

Sammut, S., Dec, A., Mitchell, D., Linardakis, J., Ortiguela, M., and West, A.R.  (2006). Phasic dopaminergic transmission increases NO efflux in the rat dorsal striatum via a neuronal NOS and a dopamine D1/5 receptor-dependent mechanism.  Neuropsychopharmacology, 31: 493-505.  Note: A cover image was included from our manuscript. 

Sammut, S., Bray, K.E., and West, A.R.   (2007).  Dopamine D2 receptor-dependent modulation of striatal NO synthase activity.  Psychopharmacology, 191: 793-803.

Sammut, S., Park, D.J., and West, A.R.  (2007).  Frontal cortical afferents facilitate striatal nitric oxide transmission in vivo via a NMDA receptor and neuronal nitric oxide synthase-dependent mechanism.  Journal of Neurochemistry, 103: 1145-1156.

Ondracek, J.M., Dec, A., Hoque, K.E., Lim, S.A., Rasouli, G., Indorkar, R.P., Linardakis, J., Klika, B.,  Mukherji, S., Burnazi, S., Threlfell, S., Sammut, S., and West, A.R. (2008).  Feed-forward excitation of striatal neuron activity by frontal cortical activation of nitric oxide signaling in vivo.  European Journal of Neuroscience, 27: 1739-1754.

Sammut, S., and West, A.R.  (2008).  Acute cocaine administration increases NO efflux in the rat prefrontal cortex via a neuronal NOS-dependent mechanism.  Synapse, 62(9):710-713.

Threlfell, S., Sammut, S., Menniti, F.S., Schmidt, C.J., and West, A.R.  (2009). Inhibition of phosphodiesterase 10A increases the responsiveness of striatal projection neurons to stimulation of frontal cortical afferents. Journal of Pharmacology and Experimental Therapeutics, 328(3): 785-795. 

Park, D., and West, A.R.  (2009). Regulation of striatal NO synthesis by local dopamine and glutamate interactions.  Journal of Neurochemistry, 111: 1457-1465.

Hoque, K.E., Indorkar, R.P., Sammut, S. and West, A.R.  (2010). Impact of dopamine-glutamate interactions on striatal neuronal nitric oxide synthase activity.  Psychopharmacology, 207: 571-581.

Sammut, S., Threlfell, S., and West, A.R.  (2010). Nitric oxide-soluble guanylyl cyclase-cGMP signaling regulates corticostriatal transmission and short-term synaptic plasticity of striatal projection neurons recorded in vivoNeuropharmacology, 58: 624-631.

Ondracek, J.M., Wiluhn, I., and Steiner, H., and West, A.R.  (2010). Interactions between procedural learning and cocaine exposure alter spontaneous and cortically-evoked spike activity in the dorsal striatum.  Frontiers in Neuroscience, 4:206. doi: 10.3389/fnins.2010.00206. 

Tseng, KY., Caballero, A., Dec, A., Cass, D.K., Simak, N., Sunu, E., Park, M.J., Blume, S.R., Sammut, S., Park, D.J. and West, A.R. (2011).  Inhibition of striatal soluble guanylyl cyclase-cGMP signaling reverses basal ganglia dysfunction and akinesia in experimental parkinsonism.  PLoS ONE, 6(11): e27187.  doi:10.1371/journal.pone.0027187.

West, A.R. and Tseng, KY. (2011). Nitric oxide-soluble guanylyl cyclase signaling in the striatum: New targets for the treatment of Parkinson's disease? Frontiers in Neuroscience, 5:1-9. doi: 10.3389/fnins.2011.00055.

Hoque, K.E., and West, A.R.  (2012).  Dopaminergic modulation of nitric oxide synthase activity in subregions of the rat nucleus accumbens. Synapse. 66: 220-231.

Threlfell, S., and West, A.R. (2013).  Modulation of striatal neuron activity by cyclic nucleotide signaling and phosphodiesterase inhibition.  Basal Ganglia.  3 (3): 137-146. dx.doi.org/10.1016/j.baga.2013.08.001.

Dec, A.M., Kohlhaas, K.L., Nelson, C.L., Hoque, K.E., Leilabadi, S.N., Folk, J., Wolf, M.E., and West, A.R.  (2013). Impact of neonatal NOS-1 inhibitor exposure on neurobehavioral measures and prefrontal-temporolimbic integration in the rat nucleus accumbens. International Journal of Neuropsychopharmacology. 17 (2): 275-287. doi: 10.1017/S1461145713000990.

Selvakumar, B., Campbell, P.W., Milovanovic, M., Park, D.J., West, A.R., Snyder, S.H., and Wolf, M.E. (2013).  AMPA receptor upregulation in the nucleus accumbens shell of cocaine-sensitized rats is mediated by S-nitrosylation of stargazing. Neuropharmacology. 77: 28-38. Published online dx.doi.org/10.1016/ j.neuropharm. 2013.08.036.

Bari, A., Dec, A., Lee, A.W., Lee, J., Song, D., Dale, E., Peterson, J., Huang, X., Campbell, B., Robbins, T.W., and West, A.R. (2015).  Enhanced inhibitory control by neuropeptide Y Y5 receptor blockade in rats.  Psychopharmacology, 232:959-973Published online dx.doi.org/10.1007/s00213-014-3730-z.

Padovan-Neto, F.E., Sammut, S., Chakroborty, S., Dec, A.M., Threlfell, S., Campbell, P.W., Mudrakola, V., Harms, J.F., Schmidt, C.J., and West, A.R. (2015). Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: Role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways.  Journal of Neuroscience. 35(14): 5781-5791.

Chakroborty, S., Kim, J., Schneider, C., West, A.R. and Stutzmann, G.E. (2015).  Nitric oxide signaling is recruited as a compensatory mechanism for sustaining synaptic plasticity in Alzheimer's disease mice.  Journal of Neuroscience. 35(17): 6893-6902.

 Book Chapters

Liu, D-T., Sammut, S., and West, A.R. (2005). Nitric oxide signaling modulates the responsiveness of striatal medium spiny neurons to electrical stimulation of the substantia nigra: Striatal nitrergic signaling. In: The Basal Ganglia VIII (Editors: Bolam, J.P., Ingham, C.A. and Magill, P.J.) Springer Science and Business Media, New York. pp 503-512.
West, A.R., Sammut, S., and Ariano, M.A. (2009). Striatal Nitric Oxide-Guanylyl Cyclase Signaling in an Animal Model of Parkinson’s Disease. In: Cortico-subcortical Dynamics in Parkinson’s Disease. (Ed. K.Y. Tseng) Humana Press. Pp 171-184.
Grace, A.A., Rosenkranz, J.A. and West, A.R. (2009).   Electrophysiology.  In: American Psychiatric Press Textbook of Psychopharmacology, Fourth Edition. (Ed. C.B. Nemeroff and A.F. Schatzberg). American Psychiatric
Press, Washington, D.C. pp 135-151. 

West, A.R. (2010). Nitric Oxide Signaling in the Striatum. In: Handbook of Basal Ganglia Structure and Function, a Decade of Progress. (Ed. H. Steiner and K.Y. Tseng) Elsevier Inc. Academic Press, London, UK. pp 187-196.

Threlfell, S., and West, A.R. (2014).  Role of cyclic nucleotide phosphodiesterases in the modulation of electrophysiological activity of central neurons. In: Cyclic-nucleotide Phosphodiesterases in the Central Nervous System: from biology to disease.  (Ed. N. Brandon and A.R. West)  John Wiley & Sons, Inc. Published online: DOI:  10.1002/9781118836507.ch11.

 Books Edited

 Cyclic-nucleotide Phosphodiesterases in the Central Nervous System: from biology to disease.  (Ed. N. Brandon and A.R. West). 2014. John Wiley & Sons, Inc. Published online: DOI:  10.1002/9781118836507.










Life in Discovery
West links
Neuroscience Faculty