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Robert Marr, Ph.D.

Assistant Professor
Department of Neuroscience
Chicago Medical School
Room 2.212
Building: BSB
Phone: 847.578.8541
Fax: 847.578.8515

KD Philibert, RA Marr, EM Norstrom, MJ Glucksman (2014). Identification and characterization of Aβ peptide interactors in Alzheimer’s disease by structural approaches. Frontiers in Aging Neuroscience. 6(265): PMC4191344

RA Marr, DM Hafez (2014). Amyloid-beta and Alzheimer’s Disease: The role of neprilysin-2 in amyloid-beta clearance. Frontiers in Aging Neuroscience. 6(187):1-7. PMC4131500

O Lazarov and RA Marr (2013). Of Mice and Men: Neurogenesis, Cognition and Alzheimer’s disease. Frontiers in Aging Neuroscience. 5:43 doi: 10.3389/fnagi.2013.00043. PMC3753540.

DM Hafez, JY Huang, JC Richardson, E Masliah, DA. Peterson, RA. Marr (2012). F-spondin gene transfer improves memory performance and reduces amyloid-β levels in mice. Neuroscience, 223: 465–472. PMID: 22863679

F Klempin, RA Marr, DA Peterson (2012). Modification of Pax6 and Olig2 in adult hippocampal neurogenesis selectively induces stem cell fate and alters both neuronal and glial populations. Stem Cells, 30(3):500-9. PMID: 22162276

JY Huang, DM Hafez, BD James, DA Bennett, RA Marr (2012). Altered NEP2 expression and activity in mild-cognitive impairment and Alzheimer’s disease. Journal of Alzheimer’s Disease, 28(2):433-41. PMID: 22008264

A Bruno, J Huang, DA Bennett, RA Marr, GE Stutzmann, and M Hastings (2011). Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging, 33(5):1001.e1–1001.e6. PMID: 21531043

BJ Spencer, RA Marr, R Gindi, R Potkar, S Michael, A Adame, E Rockenstein, IM Verma, E Masliah (2011). Peripheral delivery of a CNS targeted, metalo-protease reduces Aß toxicity in a mouse model of Alzheimer's disease. PLoS One, 6(1): 1-12 e16575. PMID: 21304989

A Gadadhar, RA Marr, O Lazarov (2011). Presenilin-1 regulates neural progenitor cell differentiation in the adult brain. Journal of Neuroscience, 31(7):2615-23. PMID: 21325529  

D Hafez, JY Huang, AM Huynh, S Valtierra, E Rockenstein,  AM Bruno, B Lu, L DesGroseillers, E Masliah, RA Marr (2011). Neprilysin-2 is an important beta-amyloid degrading enzyme. American Journal of Pathology, 178(1): 306-312. PMID: 21224067

LR Hanson, D Hafez, AL Svitak, RB Burns, X Li, WH Frey, and RA Marr (2010). Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2 deficient mice. Journal of Molecular Neuroscience, 178(1): 306-312.  PMID: 20941644

RA Marr, RM Thomas, and DA Peterson (2010). Insights into neurogenesis and aging: Potential therapy for degenerative disease? Future Neurology, 5(4): 527-541. PMID: 20806052

RA Marr and BJ Spencer (2010). NEP-like endopeptidases and Alzheimer’s disease. Current Alzheimer’s Research, 7:223-229. PMID: 20088804

O Lazarov, RA Marr (2009). Neurogenesis and Alzheimer's disease: At the crossroads. Experimental Neurology, 223:267-281. PMID: 19699201

 J Rose, L Crews, E Rockenstein, A Adame, M Mante, L Hersh, FH Gage, B Spencer, R Potkar, R Marr, and E Masliah (2009). Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. Journal of Neuroscience, 29(4):1115–1125. PMID: 19176820

B Spencer , RA Marr , E Rockenstein , L Crews , A Adame , R Potkar , C Patrick , FH Gage , IM Verma  and E Masliah (2008). Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neuroscience, 9:109. PMID: 19014502

JY Huang, AM Bruno, CA Patel, AM Huynh, KD Philibert, MJ Glucksman, RA Marr (2008). Human membrane metallo-endopeptidase-like protein (MMEL) degrades both Ab42 and Ab40. Neuroscience, 155(1):258-62. PMID: 18571334

SS El-Amouri, H Zhu, J Yu, R Marr, IM Verma, MS Kindy (2008). Neprilysin: An enzyme candidate to slow the progression of Alzheimer's disease. American Journal of Pathology, 172(5):1332-1344. PMID: 18403590

B Spencer, E Rockenstein, L Crews, R Marr, E Masliah (2007). Novel strategies for Alzheimer's disease treatment. Expert Opin Biol Ther. 7(12):1853-67. PMID: 18034651

I Hovatta, RS Tennant, R Helton, RA Marr, O Singer, JM Redwine, EE Schadt, JA Ellison, IM Verma, DJ Lockhart and C Barlow (2005). Glyoxalase 1 and glutathione reductase regulate anxiety in inbred mouse strains. Nature, 438(7068):662-6. PMID: 16244648

RA Marr*, O Singer*, E Rockenstein, L Crews, NG Coufal, FH Gage, IM Verma, and E Masliah (2005). Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nature Neuroscience, 8(10):1343-9. PMID: 16136043  * both authors contributed equally

 JC Dodart, RA Marr, M Koistinaho, BM Gregersen, S Malkani, IM Verma, SM Paul (2005). Gene delivery of human apolipoprotein E alters brain Ab burden in a mouse model of Alzheimer’s disease. Proc. Natl. Acad. Sci. U S A., 104(4):1211-1216. PMID: 15657137

 M Hashimoto, E Rockenstein, M Mante, L Crews, P Bar-On, FH Gage, R Marr, and E Masliah (2004). An antiaggregation gene therapy strategy for Lewy body disease utilizing b-synuclein lentivirus in a transgenic model. Gene Therapy, 11(23): 1713-1723. PMID: 15483670

HM Kankkonen, E Vähäkangas, RA Marr, T Pakkanen, A Laurema, P Leppänen, J Jalkanen, IM Verma, S Ylä-Herttuala (2004). Long-term lowering of serum cholesterol levels in LDL-receptor deficient WHHL rabbits by gene therapy. Molecular Therapy, 9(4):548-556. PMID: 15093185

RA Marr, H Guan, E Rockenstein, M Kindy, FH Gage, I Verma, E Masliah, LB Hersh (2004). Neprilysin regulates amyloid-b peptide levels. Journal of Molecular Neuroscience, 22(1-2):5-11. PMID: 14742905

RA Marr, E Rockenstein, A Mukherjee, MS Kindy, LB Hersh, FH Gage, IM Verma, and E Masliah (2003). Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. Journal of Neuroscience, 23(6):1992-1996. PMID: 12657655  (Featured in The Lancet 361(9363):1107 and Drug Discovery Today 8(11): 474).

Z Chen, H Huang, T Chang, S Carlsen, A. Saxena, R Marr, Z Xing, J Xiang (2002). Enhanced HER-2/neu-specific antitumor immunity by cotransduction of mouse dendritic cells with two genes encoding HER-2/neu and alpha tumor necrosis factor. Cancer Gene Therapy, 9(9): 778-786. PMID: 12189528

J Gauldie, PJ Sime, Z Xing, B Marr, and GM Tremblay (1999).  TGFß gene transfer to the lung induces myofibroblast presence and pulmonary fibrosis. Current Topics in Pathology, 93: 35-45. PMID: 10339897

RA Marr, M Hitt, J Gauldie, WJ Muller, and FL Graham (1999). A p75 TNF receptor specific mutant of murine TNFa expressed from an adenovirus vector induces an antitumour response with reduced toxicity. Cancer Gene Therapy, 6(5): 465-474. PMID: 10505857

 PJ Sime, RA Marr, D Gauldie, Z Xing, BR Hewlett, FL Graham, and J Gauldie (1998). Transfer of tumour necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts. American Journal of Pathology, 153(3): 825-832. PMID: 9736031

 RA Marr, M Hitt, WJ Muller, J Gauldie, and FL Graham (1998). Tumour therapy using adenovirus vectors expressing human TNFa. International Journal of Oncology, 12(3): 509-515. PMID: 9472086

XF Lei, Y Ohkawara, MR Stampfli, C Mastruzzo, RA Marr, D Snider, Z Xing, and M Jordana (1998). Disruption of antigen-induced inflammatory responses in CD40 ligand knock out mice. Journal of Clinical Investigations, 101(6): 1342-1353. PMID: 9502776

RA Marr, CL Addison, D Snider, WJ Muller, J Gauldie, and FL Graham (1997). Tumour immunotherapy using an adenoviral vector expressing a membrane-bound mutant of murine TNFa.  Gene Therapy, 4(11): 1181-1188. PMID: 9425441

corresponding author

 Invited Book Chapters:

Marr, RA (2011). MS: 133 | Neprilysin-2. In Handbook of Proteolytic Enzymes, 3rd edition, ND Rawlings and G Salvesen, eds, Elsevier, Ch. 128, pp. 620-624.


Marr RA (2014). Editorial on, “Amyloid-beta clearance in Alzheimer’s disease.” Frontiers in Aging Neuroscience. doi: 10.3389/fnagi.2014.00310.


Life in Discovery
Neuroscience Faculty