Robert Marr, Ph.D.

Assistant Professor
Department of Neuroscience
Chicago Medical School
Room 2.212
Building: BSB
Phone: 847.578.8541
Fax: 847.578.8515
DM Hafez, JY Huang, JC Richardson, E Masliah, DA Peterson, RA Marr  (2012).  F-spondin gene transfer improves memory performance and reduces amyloid-β levels in mice.  Neuroscience, in press.  PMID:  22863679

F Klempin, RA Marr, DA Peterson (2012).  "Modification of Pax6 and Olig2 in adult hippocampal neurogenesis selectively induces stem cell fate and alters both neuronal and glial populations."  Stem Cells, 30(3):500-9.  PMID:  22162276
JY Huang, DM Hafez, BD James, DA Bennett, RA Marr (2011). Altered NEP2 expression and activity in mild-cognitive impairment and Alzheimer’s disease. Journal of Alzheimer’s Disease, 28(2):433-41.  PMID:  22008264 

A Bruno, J Huang, DA Bennett, RA Marr, GE Stutzmann, and M Hastings (2011). Altered Ryanodine Receptor Expression in Mild Cognitive Impairment and Alzheimer's Disease. Neurobiology of Aging, doi:10.1016/j.neurobiolaging.2011.03.011. PMID: 21531043
BJ Spencer, RA Marr, R Gindi, R Potkar, S Michael, A Adame, E Rockenstein, IM Verma, E Masliah (2011). Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aß Toxicity in a Mouse Model Of Alzheimer's Disease. PLoS One, e16575. PMID: 21304989
A Gadadhar, RA Marr, O Lazarov (2011). Presenilin-1 regulates neural progenitor cell differentiation in the adult brain. Journal of Neuroscience, 31(7):2615-23. PMID: 21325529
D Hafez, JY Huang, AM Huynh, S Valtierra, E Rockenstein, AM Bruno, B Lu, L DesGroseillers, E Masliah, RA Marr (2011). Neprilysin-2 is an important beta-amyloid degrading enzyme. American Journal of Pathology. 178(1): 306-312. PMID: 21224067
LR Hanson, D Hafez, AL Svitak, RB Burns, X Li, WH Frey, and RA Marr (2010). Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2 deficient mice. Journal of Molecular Neuroscience. 178(1): 306-312.  PMID: 20941644
RA Marr, RM Thomas, and DA Peterson (2010). Insights into neurogenesis and aging: Potential therapy for degenerative disease? Future Neurology, 5(4): 527-541. PMID: 20806052
RA Marr and BJ Spencer (2010). NEP-like endopeptidases and Alzheimer’s disease. Current Alzheimer’s Research, 7:223-229. PMID: 20088804
O Lazarov, RA Marr (2009). Neurogenesis and Alzheimer's disease: At the crossroads. Experimental Neurology, 223:267-281. PMID: 19699201
J Rose, L Crews, E Rockenstein, A Adame, M Mante, L Hersh, FH Gage, B Spencer, R Potkar, R Marr, and E Masliah (2009). Neuropeptide Y Fragments Derived from Neprilysin Processing are Neuroprotective in a Transgenic Model of Alzheimer's Disease. Journal of Neuroscience, 29(4):1115–1125. PMID: 19176820
B Spencer , RA Marr , E Rockenstein , L Crews , A Adame , R Potkar , C Patrick , FH Gage , IM Verma and E Masliah (2008). Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neuroscience, 9:109. PMID: 19014502
JY Huang, AM Bruno, CA Patel, AM Huynh, KD Philibert, MJ Glucksman, RA Marr (2008). Human membrane metallo-endopeptidase-like protein (MMEL) degrades both Ab42 and Ab40. Neuroscience, 155(1):258-62. PMID: 18571334
SS El-Amouri, H Zhu, J Yu, R Marr, IM Verma, MS Kindy (2008). Neprilysin: An Enzyme Candidate to Slow the Progression of Alzheimer's Disease. Am J Pathol. 172(5):1332-1344. PMID: 18403590
B Spencer, E Rockenstein, L Crews, R Marr, E Masliah (2007). Novel strategies for Alzheimer's disease treatment. Expert Opin Biol Ther. 7(12):1853-67. PMID: 18034651
I Hovatta, RS Tennant, R Helton, RA Marr, O Singer, JM Redwine, EE Schadt, JA Ellison, IM Verma, DJ Lockhart and C Barlow (2005). Glyoxalase 1 and glutathione reductase regulate anxiety in inbred mouse strains. Nature 438(7068):662-6. PMID: 16244648
RA Marr*, O Singer*, E Rockenstein, L Crews, NG Coufal, FH Gage, IM Verma, and E Masliah (2005). Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nature Neuroscience8(10):1343-9. PMID: 16136043
* both authors contributed equally
JC Dodart, RA Marr, M Koistinaho, BM Gregersen, S Malkani, IM Verma, SM Paul(2005). Gene delivery of human apolipoprotein E alters brain Ab burden in a mouse model of Alzheimer’s disease. Proc. Natl. Acad. Sci. U S A 104(4):1211-1216. PMID: 15657137
M Hashimoto, E Rockenstein, M Mante, L Crews, P Bar-On, FH Gage, R Marr, and E Masliah (2004). An antiaggregation gene therapy strategy for Lewy body disease utilizing b-synuclein lentivirus in a transgenic model. Gene Therapy 11(23): 1713-1723. PMID: 15483670
HM Kankkonen, E Vähäkangas, RA Marr, T Pakkanen, A Laurema, P Leppänen, J Jalkanen, IM Verma, S Ylä-Herttuala (2004). Long-term lowering of serum cholesterol levels in LDL-receptor deficient WHHL rabbits by gene therapy. Molecular Therapy, 9(4):548-556. PMID: 15093185
RA Marr, H Guan, E Rockenstein, M Kindy, FH Gage, I Verma, E Masliah, LB Hersh (2004). Neprilysin regulates amyloid-b peptide levels. Journal of Molecular Neuroscience 22(1-2):5-11. PMID: 14742905
RA Marr, E Rockenstein, A Mukherjee, MS Kindy, LB Hersh, FH Gage, IM Verma, and E Masliah (2003). Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. Journal of Neuroscience 23(6):1992-1996. # PMID: 12657655 
Z Chen, H Huang, T Chang, S Carlsen, A. Saxena, R Marr, Z Xing, J Xiang (2002). Enhanced HER-2/neu-specific antitumor immunity by cotransduction of mouse dendritic cells with two genes encoding HER-2/neu and alpha tumor necrosis factor. Cancer Gene Therapy 9(9): 778-786. PMID: 12189528
J Gauldie, PJ Sime, Z Xing, B Marr, and GM Tremblay (1999).  TGFß gene transfer to the lung induces myofibroblast presence and pulmonary fibrosis. Current Topics in Pathology93: 35-45. PMID: 10339897
RA Marr, M Hitt, J Gauldie, WJ Muller, and FL Graham (1999). A p75 TNF receptor specific mutant of murine TNFa expressed from an adenovirus vector induces an antitumour response with reduced toxicity. Cancer Gene Therapy 6(5): 465-474. PMID: 10505857
PJ Sime, RA Marr, D Gauldie, Z Xing, BR Hewlett, FL Graham, and J Gauldie (1998). Transfer of tumour necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts. American Journal of Pathology 153(3): 825-832. PMID: 9736031
RA Marr, M Hitt, WJ Muller, J Gauldie, and FL Graham (1998). Tumour therapy using adenovirus vectors expressing human TNFa. International Journal of Oncology 12(3): 509-515. PMID: 9472086
XF Lei, Y Ohkawara, MR Stampfli, C Mastruzzo, RA Marr, D Snider, Z Xing, and M Jordana (1998). Disruption of antigen-induced inflammatory responses in CD40 ligand knock out mice. Journal of Clinical Investigations 101(6): 1342-1353. PMID: 9502776
RA Marr, CL Addison, D Snider, WJ Muller, J Gauldie, and FL Graham (1997). Tumour immunotherapy using an adenoviral vector expressing a membrane-bound mutant of murine TNFa.  Gene Therapy 4(11): 1181-1188. PMID: 9425441
corresponding author
# featured in The Lancet 361:1107 and Drug Discovery Today 8(11): 474
Invited Book Chapters
1. Marr, RA (2011). MS: 133 | Neprilysin-2. In Handbook of Proteolytic Enzymes, 3rd edition, ND Rawlings and G Salvesen, eds, Elsevier, pp. TBA
Life in Discovery
Neuroscience Faculty
3333 Green Bay Road, North Chicago, Il 60064-3095 • 847-578-3000