I have been conducting taste-related research for 30 years. I am currently writing a consumer-oriented book about sweeteners, which you can preview at www.sweetenerbook.com. This site contains a great deal of information about the many sweeteners that are used commercially.
Following is a list of my taste-related research publications:
Sweeteners: Discovery, Molecular Design and Chemoreception, D.E. Walters, F.T. Orthoefer, and G.E. DuBois, Eds., American Chemical Society, Washington, DC (1991).
Computer-Based Molecular Design of Artificial Flavoring Agents, A.J. Hopfinger and D.E. Walters, in Computers in Flavor and Fragrance Research, C.B. Warren and J.P. Walradt, Eds., Amer. Chem. Soc. Symp. Ser., 261, 19-32 (1984).
A Procedure for Preparing Models of Receptor Sites, D.E. Walters, R.A. Pearlstein, and C.P. Krimmel, J. Chem. Ed., 63, 869-872 (1986).
Isovanillyl Sweeteners. Amide Analogs of Dihydrochalcones, L.J. Chinn, D.E. Walters, K. Williams, and R.H. Mazur, J. Ag. Food Chem., 35, 409-411 (1987).
Molecular Modeling in the Design of New Sweeteners, D.E. Walters and J.C. Culberson, Chemical Design Automation News, 6 (5), 11-15, 1991.
Investigations of 4-Cyanophenylureas of Sweet Amino Acids as Potential Sweeteners, E.A. Hallinan, D.E. Walters, G.E. DuBois, R.H. Mazur, and G.W. Muller, J. Ag. Food Chem.. 39, 1836-1838, 1991.
Use of the Specificity Constant, Rmax/K, for Rigorous Comparisons of Sweetener Potencies, S. Roczniak and D.E. Walters, Chem. Senses, 16, 491-495, 1991.
The Rational Discovery of Sweeteners, D.E. Walters, in Sweeteners: Discovery, Molecular Design and Chemoreception, D.E. Walters, F.T. Orthoefer, and G.E. DuBois, Eds., American Chemical Society, Washington, DC (1991), pp 1-11.
Development and Utilization of a Three-Dimensional Model for the Sweet Taste Receptor, J.C. Culberson and D.E. Walters, in Sweeteners: Discovery, Molecular Design and Chemoreception, D.E. Walters, F.T. Orthoefer, and G.E. DuBois, Eds., American Chemical Society, Washington, DC (1991), pp 214-223. High Potency Sweeteners Derived from beta-Amino Acids, G.W. Muller, D.L. Madigan, J.C. Culberson, D.E. Walters, J.S. Carter, C.A. Klade, G.E. DuBois, and M.S. Kellogg, in Sweeteners: Discovery, Molecular Design and Chemoreception, D.E. Walters, F.T. Orthoefer, and G.E. DuBois, Eds., American Chemical Society, Washington, DC (1991), pp 113-125. A Systematic Study of Concentration-Response Relationships of Sweeteners, G.E. DuBois, D.E. Walters, S.S. Schiffman, Z.S. Warwick, B.J. Booth, S.D. Pecore, K. Gibes, B.T. Carr, and L.M. Brands, in Sweeteners: Discovery, Molecular Design and Chemoreception, D.E. Walters, F.T. Orthoefer, and G.E. DuBois, Eds., American Chemical Society, Washington, DC (1991), pp 261-276. Electrophysiological Evaluation of Sweeteners, G. Hellekant, D.E. Walters, J.C. Culberson, G.E. DuBois, C. Nofre, and J.-M. Tinti, in Sweeteners: Discovery, Molecular Design and Chemoreception, D.E. Walters, F.T. Orthoefer, and G.E. DuBois, Eds., American Chemical Society, Washington, DC (1991), pp 290-300.
N,N'-Disubstituted Guanidine High Potency Sweeteners, G.W. Muller, D.E. Walters and G.E. DuBois, J. Med. Chem., 35, 740-743, 1992.
Carboxylic Acid Replacement Structure-Activity Relationships in Suosan Type Sweeteners. A Sweet Taste Antagonist, G.W. Muller, J.C. Culberson, G. Roy, J. Ziegler, D.E. Walters, M.S. Kellogg, S.S. Schiffman, and Z.S. Warwick, J. Med. Chem., 35, 1747-1751, 1992.
An Example of Phylogenetic Differences in Sweet Taste: Sweetness of Five High Potency Sweeteners in Rats, G. Hellekant and D.E. Walters, in Sweet-Taste Chemoreception, M. Mathlouthi, J.A. Kanters, and G. Birch, Eds., Parthenon Publishing, 1992, pp 373-386.
The Rational Design of Ultra-High Potency Sweeteners, G.E. DuBois, D.E. Walters, and M.S. Kellogg, in Sweet-Taste Chemoreception, M. Mathlouthi, J.A. Kanters, and G. Birch, Eds., Parthenon Publishing, 1992.
On the Sense of Taste in Two Malagasy Primates (Microcebus murinus and Eulemur mongoz), G. Hellekant, C.M. Hladik, V. Dennys, B. Simmen, T.W. Roberts, D. Glaser, G. DuBois, and D.E. Walters, Chem. Senses, 18, 307-320, 1993.
High-Intensity Sweetener Blends: Sweet Choices, D.E. Walters, Food Product Design, 3 (6), 83-92, 1993.
Mechanism of Human Sweet Taste and Implications for Rational Sweetener Design, G.E. DuBois, D.E. Walters, and M.S. Kellogg, in Flavor Measurement, C.-T. Ho and C.H. Manley, Eds., Marcel Dekker, 1993, pp 239-266.
Design of Sweet and Bitter Tastants, D.E. Walters, G.E. DuBois, and M.S. Kellogg, in Mechanisms of Taste Transduction, S.A. Simon and S.D. Roper, Eds., CRC Press, 1993, pp 463-478.
Genetically Evolved Receptor Models (GERM): A Computational Approach to Construction of Receptor Models, D.E. Walters and R.M. Hinds, J. Med. Chem., 37, 2527-2536, 1994.
Using Models to Understand and Design Sweeteners, D.E. Walters, J. Chem. Ed., 72, 680-683, 1995.
When There is No Receptor Crystal Structure: Building Useful Models of Receptor Sites, D.E. Walters, NetSci: The Web Journal of Science & Computers 1, Issue 2, 1995; http://edisto.awod.com/netsci/Issues/August95/feature2.html.
How are Bitter and Sweet Tastes Related? D. E. Walters, Trends Food Sci. Technol. 7, 399-403, 1996.
Genetically Evolved Receptor Models (GERM): A Procedure for Construction of Atomic-level Receptor Site Models in the Absence of a Receptor Crystal Structure. D.E. Walters and T. D. Muhammad, in Genetic Algorithms in Molecular Modeling, J. Devillers, Ed., Academic Press, 1996, pp 193-210.
Taste Interactions of Sweet and Bitter Compounds, D.E. Walters and G. Roy, in Interactions between Flavor and Non-flavor Components, R. McGorrin and J.V. Leland, Eds., American Chemical Society, 1996, pp 130-142.
Interactions Between Sweet and Bitter Tastes. D.E. Walters, in Modifying Bitterness: Mechanism, Ingredients, Applications, G. Roy, Ed., Technomic Publishing, Lancaster, PA, 1997, pp 127-137.
New High Potency Sweeteners from Natural Sources, D.E. Walters, in Novel Food Technologies and Ingredients: Fat- and Cholesterol-reduced Foods, Bulking Agents, and High-intensity Sweeteners for Calorie-reduced Foods, S.A. Minden, Ed., International Business Communications, Southborough, MA, 1997, pp 407-413.
Genetically Evolved Receptor Models (GERM) as a 3D QSAR Tool, D.E. Walters, in 3D QSAR in Drug Design, Vol. 3, H. Kubinyi, Y.C. Martin, and G. Folkers, Eds., Kluwer Academic Publishers, Lancaster, UK, 1998, pp. 159-166.
The Active Conformations of Neotame and other High-potency Sweeteners D.E. Walters, I. Prakash, and N. Desai, J. Med. Chem., 43, 1242-1245, 2000.
Modifying the Temporal Profile of the High-Potency Sweetener Neotame. I. Prakash, I. E. Bishay, N. Desai, and D. E. Walters, J. Agric. Food Chem. 49, 786-789, 2001.
Homology-based model of the extracellular domain of the taste receptor T1R3. D.E. Walters, Pure & Appl. Chem., 74, 1117-1123, 2002.
Analysing and predicting properties of sweet-tasting compounds. D.E. Walters. In Optimising Sweet Taste in Foods, W.J. Spillane, Ed., Woodhead Publishing, Cambridge, 2006, pp. 283-291. Improving the taste of sweeteners. D.E. Walters. In Optimising Sweet Taste in Foods, W.J. Spillane, Ed., Woodhead Publishing, Cambridge, 2006, pp. 344-348.
Interactions of the sweet protein brazzein with the sweet taste receptor. D.E. Walters and G. Hellekant. J. Agric. Food Chem. 54, 10129-10133, 2006.
Computational docking to sweet taste receptor models. D.E. Walters. In Sweetness and Sweeteners: Biology, Chemistry and Psychophysics, D.K. Weerasinghe and G.E. DuBois, Eds., Oxford University Press, 2007.
Substituted Aryl Ureas as High Potency Sweeteners, D.L. Madigan, G.W. Muller, D.E. Walters, J.C. Culberson, G.E. DuBois, J.S. Carter, S. Nagarajan, R.C. Klix, D.J. Ager, C.A. Klade, Eur. Patent Appl. 89 115587.1, August 23, 1989; Eur. Patent Specification 0 355 819 B1, 1994. N, N'-Disubstituted Guanidines Containing a Carboxyl or a Tetrazolyl Moiety, G.W. Muller, D.E. Walters, and G.E. DuBois, U.S. Patent 4,900,740 (1990).