NGF References

NEUROTROPHIN MUTATIONS

• Drinkwater, CC, Barker, PA, Suter, U & Shooter, EM (1993) The carboxyl terminus of nerve growth factor is required for biological activity. J.Biol.Chem 268, 23202-23207
• Drinkwater, CC, Suter, U, Angst, C & Shooter, EM (1991) Mutation of tryptophan-21 in mouse nerve growth factor (NGF) affects binding to the fast NGF receptor but not induction of neurites on PC12 cells. Proc.R.Soc.Lond.[Biol]. 246, 307-313
• Ibanez, CF, Ebendal, T, Barbany, G, Murray-Rust, J, Blundell, TL & Persson, H (1992) Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product. Cell 69, 329-341
• Ibanez, CF, Ebendal, T & Persson, H (1991) Chimeric molecules with multiple neurotrophic activities reveal structural elements determining the specificities of NGF and BDNF. EMBO J. 10, 2105-2110
• Ibanez, CF, Hallbook, F, Ebendal, T & Persson, H (1990) Structure-function studies of nerve growth factor: functional importance of highly conserved amino acid residues. EMBO J. 9, 1477-1483
• Ibanez, CF, Ilag, LL, Murray-Rust, J & Persson, H (1993) An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin. EMBO J. 12, 2281-2293
• Ilag, LL, Curtis, R, Glass, D, Funakoshi, H, Tobkes, NJ, Ryan, TE, Acheson, A, Lindsay, RM, Persson, H, Yancopoulos, GD, DiStefano, PS & Ibanez, CF (1995) Pan-neurotrophin 1: a genetically engineered neurotrophic factor displaying multiple specificities in peripheral neurons in vitro and in vivo. Proc.Natl.Acad.Sci.U.S.A. 92, 607-611
• Kruttgen, A, Heymach, JVJr, Kahle, PJ & Shooter, EM (1997) The role of the nerve growth factor carboxyl terminus in receptor binding and conformational stability. J.Biol.Chem 272, 29222-29228
• Kullander, K & Ebendal, T (1994) Neurotrophin-3 acquires NGF-like activity after exchange to five NGF amino acid residues: molecular analysis of the sites in NGF mediating the specific interaction with the NGF high affinity receptor. J.Neurosci.Res. 39, 195-210
• Kullander, K, Kaplan, D & Ebendal, T (1997) Two restricted sites on the surface of the nerve growth factor molecule independently determine specific TrkA receptor binding and activation. J.Biol.Chem 272, 9300-9307
• Ryden, M & Ibanez, CF (1996) Binding of neurotrophin-3 to p75LNGFR, TrkA, and TrkB mediated by a single functional epitope distinct from that recognized by trkC. J.Biol.Chem 271, 5623-5627
• Ryden, M & Ibanez, CF (1997) A second determinant of binding to the p75 neurotrophin receptor revealed by alanine-scanning mutagenesis of a conserved loop in nerve growth factor. J.Biol.Chem 272, -32768
• Ryden, M, Murray-Rust, J, Glass, D, Ilag, LL, Trupp, M, Yancopoulos, GD, McDonald, NQ & Ibanez, CF (1995) Functional analysis of mutant neurotrophins deficient in low-affinity binding reveals a role for p75LNGFR in NT-4 signalling. EMBO J. 14 , 1979-1990
• Shih, A, Laramee, GR, Schmelzer, CH, Burton, LE & Winslow, JW (1994) Mutagenesis identifies amino-terminal residues of nerve growth factor necessary for Trk receptor binding and biological activity. J.Biol.Chem 269, 27679-27686
• Suter, U, Angst, C, Tien, CL, Drinkwater, CC, Lindsay, RM & Shooter, EM (1992) NGF/BDNF chimeric proteins: analysis of neurotrophin specificity by homolog-scanning mutagenesis. J.Neurosci. 12, 306-318
• Urfer, R, Tsoulfas, P, O'Connell, L & Presta, LG (1997) Specificity determinants in neurotrophin-3 and design of nerve growth factor-based trkC agonists by changing central beta-strand bundle residues to their neurotrophin-3 analogs. Biochemistry 36, 4775-4781
• Urfer, R, Tsoulfas, P, Soppet, D, Escandon, E, Parada, LF & Presta, LG (1994) The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin. EMBO J. 13, 5896-5909

CRYSTAL STRUCTURES

• Butte, MJ, Hwang, PK, Mobley, WC, & Fletterick, RJ (1998) Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors. Biochemistry 37, 16846-16852
• Holland, DR, Cousens, LS, Meng, W & Matthews, BW (1994) Nerve growth factor in different crystal forms displays structural flexibility and reveals zinc binding sites. J.Mol.Biol. 239, 385-400
• McDonald, NQ, Lapatto, R, Murray-Rust, J, Gunning, J, Wlodawer, A & Blundell, TL (1991) New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor. Nature 354, 411-414
• Robinson, RC, Radziejewski, C, Stuart, DI & Jones, EY (1995) Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer. Biochemistry 34, 4139-4146
• Bax, B, Blundell, TL, Murray-Rust, J & McDonald, NQ (1997) Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins. Structure. 5, 1275-1285

NGF coordinates: Brookhaven Data Bank file: 1BET

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