Jun 15: Dr. K.P. Chang, Professor received a new one year grant from SA Burdine Breast Foundation for his grant " Novel Cell-mediated immunotherapy for treatment of malignant diseases". $100,000
July 13: A pilot grant (100K- one year) from to the National Multiple Sclerosis Society's (2015 Illinois Pilot Research in Nervous System Damage, Repair or Rehabilitation in Multiple Sclerosis) is funded. “Association between viral load and encephalitogenic T cell activation in Multiple Sclerosis.”
This grant is by the efforts of CMS-RFUMS- M and I dept faculty Dr. David Everly and Dr. Joe Reynold and Dr. Matthew Sorenson from DePaul University.(Dr. Sorenson is the Associate Director, Master's Entry to Nursing Practice Program; Associate Professor, Nursing PhD, APN, ANP-C, School of Nursing).
July 31: Dr. Gulam Waris, Assistant Professor is awarded with a one year Northern Illinois University- RFUMS pilot project grant. Drs. Waris, Elsawa and Bode. " GLI-mediated inflammation in Response to HCV-HBV infection". $49,500.
Dr. Neelam Sharma-Walia, Assistant Professor is awarded with a one year Northern Illinois University- RFUMS pilot project grant. Drs. Sharma-Walia and Elsawa. " Role of GLI2 in Inflammatory Breast cancer": $45,000
June 29, 2015 - Present
June 29: A manuscript by Dr. Dipanjan Dutta and Dr. Sujoy Dutta from Dr. Bala Chandran’s laboratory is published in PLos Pathogens (Impact Factor: 8.06) BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses.Dutta D, Dutta S, Veettil MV, Roy A, Ansari MA, Iqbal J, Chikoti L, Kumar B, Johnson KE, Chandran B. PLoS Pathog. 2015 Jun 29;11(6):e1005030. doi: 10.1371/journal.ppat.1005030. eCollection 2015 Jun. PMID: 26121674
July 2: A manuscript by Dr. Mairaj A Ansari, Post-doctoral fellow with Dr. Bala Chandran is published in PLos Pathogens (Impact Factor: 8.06) :Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses.Ansari MA, Dutta S, Veettil MV, Dutta D, Iqbal J, Kumar B, Roy A, Chikoti L, Singh VV, Chandran B. PLoS Pathog. 2015 Jul 2;11(7):e1005019. doi:10.1371/journal.ppat.1005019. eCollection 2015 Jul. PMID: 26134128.
Aug 27: A paper by Sahithi Pamarthy, Ph.D student under the supervision of Dr. K. Beaman has been accepted for publicationin Oncotarget (Impact Factor: 6.359).“The Vacuolar ATPase a2-subunit regulates Notch signaling in Triple Negative Breast Cancer cells “ Sahithi Pamarthy, Mukesh K Jaiswal, Arpita Kulshreshta, Gajendra K Katara, Alice Gilman-Sachs and Kenneth D Beaman.
Aug 31: A manuscript by Safaa A. Ibrahim, Ph.D student (Egypt) under Dr. Beaman has been accepted for publication in Oncotarget ( Impact factor 2014: 6.359) . "Breast Cancer Associated a2 Isoform Vacuolar ATPase Immunomodulates Neutrophils: Potential Role in Tumor Progression" . Safaa A. Ibrahim, Gajendra K. Katara, Arpita Kulshrestha, Mukesh K. Jaiswal, Magdy A. Amin and Kenneth D. Beaman.
Aug 31: A collaborative research work paper from the laboratories of Dr. Beaman and Dr. Hirsch has been accepted for publication in the Journal of Leukocyte Biology. "Role of Notch Signaling during Lipopolysaccharide-Induced Preterm Labor" Varkha Agrawal#,§, Mukesh K. Jaiswal*,§, Sahithi Pamarthy*, Gajendra K. Katara*, Arpita Kulshrestha*, Alice Gilman-Sachs*, Emmet Hirsch#¶, and Kenneth D. Beaman*. Based on the impact of their findings, JLB will feature the manuscript under the Frontline Science Section as "Leading Edge Research" in the Table of Contents with a dedicated editorial for the benefit of readers to gain greater insight from our findings.
July 1, 2014 thru June 30, 2015
*CMS student **Graduate Student
1. Peer-Reviewed Publications
Chang, KP. Vaccination for Disease Prevention and Control: The Necessity of Renewed Emphasis and New Approaches. J Immunol Immunotech. July 2014; 1(1): 1-4.
Sahoo M., L. del Barrio, M.A. Miller, and F. Re. Neutrophil elastase causes tissue damage that decreases host tolerance to lung infection with Burkholderia species. PLoS Pathog. August 2014 10(8): e1004327.
Smith AR, and JM Reynolds. The contribution of myeloid-derived suppression to inflammatory disease. Journal of Leukocyte Biology September 2014, 96: 361-364.
Ota K, S Yamagishi, M. Kim, S. Dambaeva, A. Gilman-Sachs, K. Beaman, J. Kwak-Kim. Elevation of soluble form of receptor for advanced glycation end products (sRAGE) in recurrent pregnancy losses (RPL): possible participation of RAGE in RPL. Fertil Steril. September 2014 102(3):782-9.
Valiya Veettil M, V. Bottero, D. Dutta, C. Bandyopadhyay, O. Gjyishi, N. Shrama-Walia, S. Dutta, and B. Chandran. Glutamate secretion and mGluR1 expression during Kaposi’s sarcoma associated herpesvirus infection promotes cell proliferation. PLoS Pathog. October 2014 10(10):e1004389.
Gjyshi O, V. Bottero, M. Valliya Veettil, S. Dutta, VV. Singh, L. Chikoti and B. Chandran. Kaposi’s Sarcoma-Associated Herpesvirus Induces Nrf2 During De Novo Infection of Endothelial Cells to Create a Microenvironment Conducive to Infection. PLoS Pathog. October 2014 10(10):e1004460.
Johnson KE, V. Bottero, S. Flaherty, VV. Singh, and B. Chandran. IFI16 Restricts HSV-1 Replication by Accumulating on the HSV-1 Genome, Repressing HSV-1 Gene Expression, and Directly or Indirectly Modulating Histone Modifications. PLoS Pathog. November 2014. 10(11):e1004503.
Agrawal, V., M. K. Jaiswal, V. Ilievski, K. D. Beaman, T. Jilling, and E. Hirsch. Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. Biology of Reproduction Nov. 2014. 91: 119.
Beaman KD, M.K. Jaiswal, S. Dambaeva, A. Gilman-Sachs. Future directions of clinical laboratory evaluation of pregnancy. Cell Mol Immunol. Nov 2014. 11(6):582-8.
Katara, G.K., M.K. Jaiswal, A. Kulshrestha, B. Kolli, A. Gilman-Sachs and K.D. Beaman. Tumor-associated vacuolar ATPase subunit promotes tumorigenic characteristics in macrophages. Oncogene December 2014. 4;33(49):5649-54.
Bandyopadhyay C, M. Valliya Veettil, S. Dutta, and B. Chandran. p130Cas Scaffolds the Signalosome to Direct Adaptor-Effector Crosstalk During Kaposi’s Sarcoma-Associated Herpesvirus Trafficking in Human Microvascular Dermal Endothelial Cells. J Virol. December 2014. 88(23):13858-78.
Gjyshi O, S. Flaherty, MV Veettil, KE Johnson, B. Chandran, V. Bottero. Kaposi's Sarcoma-Associated Herpesvirus Induces Nrf2 Activation in Latently Infected Endothelial Cells through SQSTM1 Phosphorylation and Interaction with Polyubiquitinated Keap1. J Virol. February 2015. 89(4):2268-86.
Gjyshi O and B. Chandran. Manipulating host signaling for pathogenic purposes: Hijacking of the transcriptional activity of the host protein Nrf2 by Kaposi’s sarcoma-associated herpesvirus. Science Proceedings Feb 2015. 2:e599.
Kulshrestha, A., G. K. Katara, S. Ibrahim, S. Pamarthy, M. K. Jaiswal, A. G. Sachs and K. D. Beaman. Vacuolar ATPase 'a2' isoform exhibits distinct cell surface accumulation and modulates matrix metalloproteinase activity in ovarian cancer. Oncotarget Feb 2015 ;6(6):3797-810.
del Barrio L., M. Sahoo, L. Lantier, J.M. Reynolds, I. Ceballos-Olvera, and F. Re. Production of anti-LPS IgM by B1a B cells depends on IL-1b and is protective against lung infection with Francisella tularensis LVS. PLoS Pathog. March 2015. 11(3): e1004706.
Agrawal V, M.K. Jaiswal, T. Mallers, G.K. Katara, A. Gilman-Sachs, K.D. Beaman, Hirsch Altered autophagic flux enhances inflammatory responses during inflammation-induced preterm labor. E.Sci Rep. March 2015. 23;5:9410.
James SJ, H. Jiao, H. The, H. Takahashi, C.W. Png, M.C. Phoon, Y. Suzuki, T. Sawasaki, H. Xiao, VTK Chow, N. Yamamoto, J.M. Reynolds, R.A. Flavell, C. Dong. MAP kinase phosphatase 5 induced by influenza and other RNA virus infection negatively regulates IRF3 activation and type I interferon response. Cell Reports, March 2015. 10: 1722-34.
Marginean A, N. Sharma-Walia. Lipoxins exert antiangiogenic and anti-inflammatory effects on Kaposi's sarcoma cells. Translational research : the journal of laboratory and clinical medicine. March 2015. pii: S1931-5244(15)00084-5.
Zhang Y, KC Nallaparaju, X. Liu, H. Jiao, JM Reynolds, Z. Wang, C. Dong. MAPK phosphatase 7 regulates T cell differentiation via inhibiting ERK-mediated IL-2 expression. Journal of Immunology April 2015, 194(7): 3088-95
Flaherty S, JM Reynolds. Naïve CD4+ T cell isolation from mouse and in vitro differentiation to T cell subsets. Journal of Visual Experimentation, April 2015. 98.
Reynolds JM, YH Lee, Y. Shi, P. Angkasekwinai, KC Nallaparaju, S. Flaherty, SH Chang, H. Watarai, C. Dong. Interleukin-17B antagonizes interleukin-25-mediated mucosal inflammation. Immunity, April 2015. 42(4): 692-703.
Katara, G.K., A. Kulshrestha, M. K. Jaiswal, S. Pamarthy, A. Gilman-Sachs, and K. D. Beaman. Inhibition of vacuolar ATPase subunit in tumor cells delays tumor growth by decreasing the essential macrophage population in the tumor microenvironment. Oncogene. May 2015. doi: 10.1038
Zhang Y, T. Nguyen, P. Tang, NJ Kennedy, H. Jiao, M. Zhang, JM Reynolds, A. Jaeschke, N. Martin-Orozco, Y. Chung, W. He, C. Wang, W. Jia, B. Ge, RJ Davis, RA Flavell, and C. Dong. “Regulation of adipose tissue inflammation and insulin resistance by MAP kinase phosphatase 5”. The Journal of Biological Chemistry June 2015. 290(24):14875-83.
Gilman-Sachs A, A. Tikoo, L. Akman-Anderson, M. Jaiswal, E. Ntrivalas, K. Beaman. Expression and role of a2 vacuolar-ATPase (a2V) in trafficking of human neutrophil granules and exocytosis. J Leukoc Biol. June 2015; 97(6):1121-31.
Dutta D, S. Dutta, MV Veettil, A. Roy, MA Ansari, J. Iqbal, L. Chikoti, B. Kumar, KE Johnson, B. Chandran. BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses. PLoS Pathog. June 2015. 11(6):e1005030.
Shio MT, JG Christian, JY Jung, KP Chang, M. Olivier. PKC/ROS-Mediated NLRP3Inflammasome Activation Is Attenuated by Leishmania Zinc-Metalloprotease duringInfection. PLoS Negl Trop Dis. June 2015. 26;9(6):e0003868
2. Book Chapters and Review Articles
Chang, KP. Leishmaniasis. In: Reference module in Biomedical Sciences, Michael Caplan Ed., 2014, July 24th, Elsevier, Oxford, UK
Chang KP. Leishmaniases. In: Encyclopedia of Life Sciences, Volume 27, Chapter 688, 3rd Edition, 2014, Aug. 26, Academic Press, an imprint of ELSEVIER INC, San Diego, USA.
Valiya Veettil M, C. Bandyopadhyay, D. Dutta, and B. Chandran. Interaction of KSHV with Host Cell Surface Receptors and Cell Entry. Viruses. 2014 Oct 23;6(10):4024-4046. Review
July 1, 2014 thru June 30, 2015
Abstracts Published and Poster Presentations
Iqbal, J., S. McRae, M. Sarkar-Dutta, K. Banaudha, and G. Waris. Role of hepatitis C virus induced osteopontin in EMT, migration and invasion of hepatocytes. Presented at 2nd Annual FHCC/RFUMS Research Poster Day at FHCC on July 3, 2014.
Jaiswal M.K., Agrawal V., Sahithi Pamarthy, Gilman-Sachs A., Hirsch E., and Beaman K. D. (2014) -Notch signaling is notched up in inflammation-induced preterm labor SSR, Grand Rapid, MI, USA from July 19-23, 2014.
Valiya Veettil M, Bottero V, Dutta D, Bandyopadhyay C, Gjyishi O, Shrama-Walia N, Dutta S, and Chandran B. Glutamate secretion and mGluR1 expression during Kaposi’s sarcoma associated herpesvirus infection promotes cell proliferation. 39th International Herpesvirus workshop, Kobe, Japan. July 19-July 24, 2014.
Johnson KE, Bottero V, Flaherty S, Singh VV, and Chandran B. IFI16 Restricts HSV-1 Replication by Accumulating on the HSV-1 Genome, Repressing HSV-1 Gene Expression, and Directly or Indirectly Modulating Histone Modifications. 39th International Herpesvirus workshop, Kobe, Japan. July 19-July 24, 2014.
Talaty P., K. Holthusen, and D. Everly, “Epstein-Barr Virus and Human Cancer.” FHCC/RFUMS Research Poster Day on July 31st 2014, North Chicago, IL
Sharma-Walia N., K. Chandran*, K. Patel, M.V. Veettil, and A. Marginean. “The KSHV induced 5-lipoxygenase-leukotriene B4 (5LO/LTB4) cascade plays key roles in KSHV latency, monocyte recruitment and lipogenesis”. RFUMS-FHCC retreat, Research Poster Day, July 31st, 2014.
Chavalit Sitapradit*, Pooja Talaty, and David N. Everly Jr., “Analysis of the Latent Membrane Protein 1 Signaling Complex of Epstein-Barr Virus Using BioID” RFUMS CMS Summer Research, October 31, 2014.
Patrick, S*., J. A. Chandarashekharan, S. Lakemacher, and Sharma-Walia, N. “Kaposi's sarcoma-associated herpesvirus (KSHV) induced leukotriene A4 hydrolase plays key role in KSHV latently infected cell survival” Chicago Medical School Summer Research Poster presentation, RFUMS, North Chicago, Illinois, October 31st, 2014.
Chang KP, Kolli BK, Tripathi P, Ng DKP, Chang CS, Alkahtani S, Al-Qahtani A, de Oliveira CI, Mello S, Manna L, Head JF, Elliott RL, Batchu RB. Photodynamic vaccination: Novel strategies of vaccine delivery by intraphagolysosomal parasites and their oxidative inactivation for safe and effective applications, 2014, Nov. 17. 2nd Int Congr Bacteriol Inf Dis, Chicago, IL, USA.
Goswami S**, Sharma-Walia N. “Fatty acid synthase, cycloxygenase-2 (COX-2) and osteoprotegerin (OPG) expression in invasive breast cancer: implications in carcinogenesis”. Mar 3rd, 2015 All-School Research Consortium, RFUMS, North Chicago, Illinois.
Chandrasekharan A. J** and Sharma-Walia N. “The Role of lipoxins in KSHV biology”. Mar 3rd, 2015 All-School Research Consortium, RFUMS, North Chicago, Illinois.
Chandran, K*. and Sharma-Walia N. “Implications of a peroxisome proliferator-activated receptor alpha (PPAR-a) ligand Clofibrate in Inflammatory and Invasive breast cancer”. Mar 3rd, 2015 All-School Research Consortium, RFUMS, North Chicago, Illinois.
Chandran, K*. and Sharma-Walia N. “Implications of a peroxisome proliferator-activated receptor alpha (PPAR-a) ligand Clofibrate in Inflammatory and Invasive breast cancer”. March 13-14, Chicago Medical Society Midwest Clinical Conference Research Symposium, held in Chicago, Illinois.
Pooja Talaty, et al., “The impact of human milk fortification on human milk properties.” RFUMS ASRC, March 18, 2015.
Jason J McAloon, Pooja Talaty, Jun-Yong Choe, David Everly, “Recombinant Expression and Purification of Latent Membrane Protein 1 of Epstein-Barr Virus: Potential Insights Into Oligomerization and Lipid Raft Association.” RFUMS ASRC, March 18, 2015.
Daniel Grahf*, Pooja Talaty, David Everly, “Coupling of Bimolecular Fluorescent Complementation and Next-Generation Sequencing to Uncover Novel Protein Interactions in the LMP1 Signaling Pathway of EBV.” RFUMS ASRC, March 18, 2015.
Goswami S**, Sharma-Walia N. “Fatty acid synthase, cycloxygenase-2 (COX-2) and osteoprotegerin (OPG) expression in invasive breast cancer: implications in carcinogenesis”. April 18 - 22, 2015, AACR Annual Meeting 2015, Philadelphia, Pennsylvania.
Pamarthy, S., M. K. Jaiswal, A. Kulshrestha, G. Katara, S. Ibrahim, A. Gilman-Sachs and K. D. Beaman. 2015. The Baffling Effect of Bafilomycin on Notch Signaling in Triple Negative Breast Cancer. American Association for Cancer Research Annual Meeting. 2015 held at Philladelphia, PA, USA from April 18-22, 2015.
Arpita Kulshrestha , Gajendra Kumar Katara, Sahithi Pamarthy, Safaa A. Ibrahim, Alice Gilman-Sachs, Kenneth D. Beaman. Tumor cell surface-associated vacuolar-ATPase ‘a2’ isoform promotes invasion by regulating matrix metalloproteinase activity in ovarian cancer. At American Association for Cancer Research annual meeting -2015 held at Philladelphia, PA, USA from April 18-22, 2015.
Gajendra K. Katara , Arpita Kulshrestha, Alice Gilman-Sachs and Kenneth D. Beaman. Delayed tumor growth in breast cancer is associated with reduced activity of the a2 isoform of vacuolar ATPase. At American Association for Cancer Research annual meeting -2015 held at Philladelphia, PA, USA from April 18-22, 2015.
Valiya Veettil M, Dutta D, Bottero V, Bandyopadhyay C, Gjyshi O, Sharma-Walia N, Dutta S, Chandran B. KSHV induces glutamate secretion and metabotropic glutamate receptor1 expression: Implications for cell proliferation and targeted therapy. The 21st Annual Scientific Conference of the Society on Neuroimmune Pharmacology. April 22-25, 2015. Miami, Florida.
Goswami S** and Sharma-Walia N. “Fatty acid synthase, cycloxygenase-2 (COX-2) and osteoprotegerin (OPG) expression in invasive breast cancer: implications in carcinogenesis”. CSCTR/MWAFMR Combined Annual Meeting in Chicago, IL April 23rd-24th, 2014.
Chandrasekharan A. J. ** and Sharma-Walia N. “The Role of lipoxins in KSHV biology”. CSCTR/MWAFMR Combined Annual Meeting in Chicago, IL April 23rd-24th, 2014.
Yogendran, L.* and Sharma-Walia N. “Sphingosine kinase inhibitors: Potential chemotherapeutic modality for inflammatory breast cancer”. CSCTR/MWAFMR Combined Annual Meeting in Chicago, IL April 23rd-24th, 2014.
Patrick, S. *, J. A. Chandarashekharan, S. Lakemacher, and Sharma-Walia, N. “Kaposi's sarcoma-associated herpesvirus (KSHV) induced leukotriene A4 hydrolase plays key role in KSHV latently infected cell survival”. CSCTR/MWAFMR Combined Annual Meeting in Chicago, IL April 23rd-24th, 2014.
Pisano G. and D. Everly, “The Role of Ubiquitination in NF-kB Signaling Induced by the EBV Oncogene LMP1.” Chicago Symposium on Cell Signaling, May 21, 2015, Northwestern University, Chicago, IL USA
McRae S., J. Iqbal, M. Sarkar-Dutta, N. Ali and G. Waris. Hepatitis C virus-induced NLRP3-inflammasome complex regulates lipid metabolism. 2015 Chicago Symposium on Cell Signaling on May 21, 2015 at Robert H. Lurie Medical Research Center, Northwestern University, Chicago.
Bandyopadhyay C, Valiya Veettil M, Dutta S, Kumar B, and Chandran B. p130Cas Scaffolds the Signalosome to Direct Adaptor-Effector Crosstalk During Kaposi’s Sarcoma-Associated Herpesvirus Trafficking in Human Microvascular Dermal Endothelial Cells. Chicago Symposium on Cell Signaling, May 21, 2015.