Carl White

Physiology and Biophysics Faculty
Boudko, Dmitri Y. Bradbury, Neil Bridges, Robert J. Ebihara, Lisa	Hawkins, Richard A Kim, Donghee Najmabadi, Feridoon McCormack, Charles E. Peterson, Darryl R. Rasgado-Flores, Hèctor	Sackin, Henry Sukowski, Ernest J. Urban, Janice Carl White
Second Appointment
Garber, Sarah S. Gazmuri, Raul J.	Hansen, Timothy R. Pullen, Gordon L.	Singh, Sant Zikos, Demetrios

Carl White
Assistant Professor of Physiology and Biophysics
Phone: 847-578-8358
E-mail: carl.white@rosalindfranklin.edu

Calcium Signaling

The modulation of intracellular calcium is a signaling system involved in the regulation of numerous cellular processes, including transepithelial transport, learning and memory, muscle contraction, membrane trafficking, synaptic transmission, secretion, motility, membrane excitability, gene expression, cell division and apoptosis. Our research effort is focused on understanding the mechanisms that underlie the generation, propagation and regulation of these calcium signals. To do this we employ a broad range of experimental approaches that include electrophysiology and calcium imaging as well as molecular and biochemical techniques.

We are especially interested in the behavior of inositol 1,4,5-trisphosphate intracellular calcium release channels (InsP₃Rs). The InsP₃Rs are a family of ubiquitously expressed calcium channels localized predominately in the endoplasmic reticulum and function to release calcium into the cytoplasm in response to extracellular stimuli. In particular, we are interested in how proteins regulate the basic electrophysiological properties of the channel and how this modifies the calcium signal at the cellular level. Ultimately, we hope to understand how these signals are then decoded by their cellular targets.

Recent Publications

Wang, X., Olberding, K.E., White, C. and Li, C. (2010) Bcl-2 proteins regulate ER membrane permeability to luminal proteins during ER stress-induced apoptosis. Cell Death & Differentiation. (in press). [PubMed]

Paul, A.G., Sharma-Walia, N., Kerur, N., White, C. & Chandran, B. (2010) Piracy of Prostaglandin E2/EP Receptor–Mediated Signaling by Kaposi's Sarcoma-Associated Herpes Virus (HHV-8) for Latency Gene Expression: Strategy of a Successful Pathogen. Cancer Research. 70(9), 3697- 3708. [PubMed]

Eckenrode, E.F., Yang, J., Velmurugan,G.V., Foskett, J.K. and White, C. (2010) Apoptosis Protection by Mcl-1 and Bcl-2 Modulation of Inositol 1,4,5-Trisphosphate Receptor-dependent Ca²⁺ Signaling. Journal of Biological Chemistry. 285(18), 13678-13684. [PubMed]

Li, C., Wang, X., Vais, H., Thompson, C.B., Foskett, J.K. and White, C.(2007). Apoptosis regulation by Bcl-x_L modulation of mammalian InsP₃R channel isoform gating. PNAS, 104(30), 12565-70. [PubMed]

Jones, R.G., Bui, T., White, C., Madesh, M., Krawczyk, C.M., Frauwirth, K.A., Kubek, S., Wang, L.Y., Hawkins, B.J., Lindsten, T., Conway, S., Roderick, H.L., Bootman, M.D., Shen, H., Foskett, J.K. and C. B. Thompson. (2007). Bax and Bak regulate T cell proliferation through control of ER Ca²⁺ homeostasis. Immunity, 27(2), 268-280. [PubMed]

Mak, D.-O.D., White, C., Ionescu, L. and Foskett, J.K. (2007). The inositol trisphosphate receptor Ca²⁺ release channel. Physiological Reviews. 87(2), 5923- 658. [PubMed]

White, C., Yang, J., Monteiro, M.J. and Foskett, J.K. (2006). CIB1, a ubiquitously-expressed Ca²⁺-binding protein-ligand of the InsP₃ receptor Ca²⁺-release channel. Journal of Biological Chemistry. 281(30), 20825-20833[PubMed]

Ionescu, L., Cheung, K.H., Vais, H., Mak, D.O., White, C. and Foskett, J.K. (2006). Graded recruitment and inactivation of single InsP₃ receptor Ca²⁺ channels. Journal of Physiology. 573, 645-662. [PubMed]

White, C.,Chi, L., Yang, J., Petrenko, N., Muniswamy, M., Thompson, C.B. & J. K. Foskett (2005). The endoplasmic reticulum gateway to apoptosis: Bcl-X_L modulation of the InsP₃ receptor. Nature Cell Biology. 7, 1021-1028. [PubMed]

Mak, D.-O.D., White, C., Ionescu, L. and Foskett, J.K. (2005). Nuclear patch clamp electrophysiology of inositol trisphosphate receptor Ca²⁺ release channels. In Putney, J.W., Jr.(ed), Calcium Signaling, 2^nd Ed. CRC Press, Boca Raton.

Department of Physiology and Biophysics

Calcium Signaling